Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7578023 | 0.83 | P2RX7 (0.49) | MEN1KMT2AKDM4EALDH1A1P2RX7 | |
| SCHEMBL7571520 | 0.80 | P2RX7 (0.58) | MEN1KMT2AALDH1A1P2RX7 | |
| SCHEMBL7572957 | 0.75 | RAB9A (0.48) | MEN1KMT2AKDM4EALDH1A1ATM | |
| SCHEMBL7571514 | 0.71 | ALDH1A1 (0.51) | MEN1KMT2AKDM4EALDH1A1P2RX7 | |
| SCHEMBL19524633 | 0.71 | P2RX7 (0.64) | ALDH1A1P2RX7EPHX2 | |
| SCHEMBL7570515 | 0.70 | P2RX7 (0.47) | MEN1KMT2AKDM4EALDH1A1P2RX7 | |
| SCHEMBL7572606 | 0.69 | P2RX7 (0.60) | MEN1KMT2AALDH1A1P2RX7 | |
| SCHEMBL7572642 | 0.69 | P2RX7 (0.43) | MEN1KMT2AKDM4EALDH1A1P2RX7 | |
| Hydrochloric Acid SCHEMBL7570206 | 0.69 | P2RX7 (0.48) | MEN1KMT2AKDM4EALDH1A1ATM | |
| SCHEMBL15537079 | 0.68 | MAPT (0.63) | MEN1KMT2AALDH1A1ATMP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019382-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH SERINE PROTEASE, PARTICULARLY TRYPTASE, ACTIVITY | AXYS PHARMACEUTICALS, INC. (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-2000020400-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING HEPATITIS C INFECTIONS | AXYS PHARMACEUTICALS, INC. (US) | 2000-04-13 | — | — | WO | disclosed |
| WO-1999026933-A1 | SUBSTITUTED AMIDINOARYL DERIVATIVES AND THEIR USE AS ANTICOAGULANTS | AXYS PHARMACEUTICALS, INC. (US) | 1999-06-03 | — | — | WO | disclosed |
| WO-1998045275-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH SERINE PROTEASE, PARTICULARLY TRYPTASE, ACTIVITY | AXYS PHARMACEUTICALS CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |