SCHEMBL7579452

SCHEMBL7579452

COc1cc(OC)nc(NC(=O)NS(=O)(=O)Cc2ccccc2C(=O)O)n1.C[C@H](OC(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1Cl)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.38
TTR P02766 1/20 0.38
PPOX P50336 1/20 0.38
KMT2A Q03164 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
LMNA P02545 2/20 0.36
KDM4E B2RXH2 1/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 1/20 0.36
FFAR1 O14842 2/20 0.36
THRB P10828 1/20 0.36
MRGPRX4 Q96LA9 5/20 0.36
PYGL P06737 1/20 0.33
PYGM P11217 1/20 0.33
SCN8A Q9UQD0 1/20 0.33
SCN10A Q9Y5Y9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acifluorfen SCHEMBL7578502 0.85 TDP1 (0.57) MEN1TTRPPOXKMT2ATDP1
SCHEMBL7596990 0.84 LMNA (0.39) MEN1TTRPPOXKMT2ATDP1
Ethoxysulfuron SCHEMBL7580414 0.84 TP53 (0.37) MEN1TTRPPOXKMT2ATDP1
Flupyrsulfuron SCHEMBL7580422 0.84 KMT2A (0.40) MEN1TTRPPOXKMT2ATDP1
SCHEMBL7589011 0.83 MEN1 (0.37) MEN1TTRPPOXKMT2ATDP1
Primisulfuron SCHEMBL7578606 0.83 MEN1 (0.38) MEN1TTRPPOXKMT2ATDP1
Chlorimuron Ethyl SCHEMBL7582578 0.83 MRGPRX4 (0.36) MEN1TTRPPOXKMT2ATDP1
Flazasulfuron SCHEMBL7578001 0.82 LMNA (0.38) MEN1TTRPPOXKMT2ATDP1
Halosulfuron SCHEMBL7580413 0.82 LMNA (0.36) MEN1TTRPPOXKMT2ATDP1
Rimsulfuron SCHEMBL7575973 0.82 LMNA (0.35) MEN1TTRPPOXKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020004457-A1 Herbicidal composition SYNGENTA PARTICIPATIONS AG (CH) 2002-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020004457-A1 Herbicidal composition PPOX, ALAD, DDT MEN1 4274/4885TTR 1945/4885PPOX 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.