Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6043926 | 0.76 | REN (0.51) | ALDH1A1KDM4EHPGDREN | |
| SCHEMBL6043121 | 0.71 | CASR (0.47) | ALDH1A1GAA | |
| SCHEMBL7585763 | 0.69 | REN (0.41) | ALDH1A1REN | |
| SCHEMBL6042963 | 0.68 | MCHR1 (0.41) | MAPTALDH1A1SMN1; SMN2GAAREN | |
| SCHEMBL6043085 | 0.68 | MCHR1 (0.41) | MAPTALDH1A1SMN1; SMN2GAAREN | |
| SCHEMBL1241355 | 0.68 | LTA4H (0.64) | LTA4HALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL501988 | 0.68 | HRH3 (0.75) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL3366608 | 0.67 | LTA4H (0.78) | LTA4HALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL4420934 | 0.67 | NPC1 (0.65) | LTA4HALDH1A1KDM4ESMN1; SMN2HRH3 | |
| SCHEMBL991354 | 0.66 | ALDH1A1 (0.76) | MAPTLTA4HALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076440-A2 | METHODS OF TREATING ALZHEIMER'S DISEASE WITH PIPERIDIN DERIVATES | ELAN PHARMACEUTICALS, INC. (US) | 2002-10-03 | — | — | WO | disclosed |