Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 9/20 | 0.36 |
| ▸ | DRD3 | P35462 | 9/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7587091 | 0.92 | P2RX7 (0.41) | P2RX7LMNADPP4DRD2DRD3 | |
| SCHEMBL7583788 | 0.89 | P2RX7 (0.41) | P2RX7LMNADPP4DRD2DRD3 | |
| SCHEMBL7582092 | 0.84 | P2RX7 (0.40) | P2RX7FFAR2DPP4DRD2DRD3 | |
| SCHEMBL7585483 | 0.83 | P2RX7 (0.41) | P2RX7LMNAFFAR2DPP4DRD2 | |
| SCHEMBL7583781 | 0.82 | P2RX7 (0.51) | P2RX7FFAR2MAOA | |
| SCHEMBL7589899 | 0.82 | NAAA (0.45) | P2RX7DPP4DRD2DRD3 | |
| SCHEMBL27419636 | 0.81 | P2RX7 (0.40) | P2RX7LMNADPP4DRD2DRD3 | |
| SCHEMBL7590018 | 0.81 | DRD2 (0.41) | P2RX7LMNADRD2DRD3 | |
| SCHEMBL7583792 | 0.79 | DRD2 (0.41) | P2RX7LMNADRD2DRD3 | |
| SCHEMBL7583803 | 0.78 | DRD2 (0.39) | P2RX7LMNADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |