SCHEMBL758323

SCHEMBL758323

CS(=O)(=O)c1ccc2ccccc2c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.66
LMNA P02545 1/20 0.63
L3MBTL1 Q9Y468 1/20 0.62
PTGS2 P35354 1/20 0.58
F2 P00734 1/20 0.52
PRSS1 P07477 1/20 0.52
PRSS2 P07478 1/20 0.52
PRSS3 P35030 1/20 0.52
AKR1C3 P42330 2/20 0.51
AKR1C2 P52895 2/20 0.51
GAA P10253 1/20 0.51
MCOLN3 Q8TDD5 2/20 0.50
PKM P14618 2/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
TSHR P16473 1/20 0.50
PKLR P30613 1/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15624757 0.93 ATM (0.59) ATMLMNAL3MBTL1PTGS2F2
SCHEMBL12508320 0.91 AKR1C3 (0.58) ATMLMNAL3MBTL1PTGS2AKR1C3
SCHEMBL13203351 0.88 AKR1C3 (0.52) ATMLMNAL3MBTL1PTGS2AKR1C3
SCHEMBL7898626 0.84 CA1 (0.68) ATMLMNAL3MBTL1PTGS2CA1
SCHEMBL30712199 0.84 CA1 (0.68) ATMLMNAL3MBTL1PTGS2CA1
SCHEMBL13561723 0.83 ATM (0.50) ATMLMNAL3MBTL1PTGS2F2
SCHEMBL12277758 0.83 ATM (0.50) ATMLMNAL3MBTL1PTGS2F2
SCHEMBL8243698 0.83 LMNA (0.59) ATMLMNAL3MBTL1F2PRSS1
SCHEMBL2286348 0.83 LMNA (0.59) ATMLMNAL3MBTL1F2PRSS1
SCHEMBL29800886 0.83 LMNA (0.59) ATMLMNAL3MBTL1F2PRSS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 219 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101034260-B Photosensitive resin composition DONGJIN SEMICOHEM CO LTD 2012-07-18 CN claimed
US-20080207706-A1 THIADIAZOLINE DERIVATIVE KYOWA HAKKO KOGYO CO., LTD (JP) 2008-08-28 US claimed
CN-101034260-A Photosensitive resin composition DONGJIN SEMICHEM CO LTD (KR) 2007-09-12 CN claimed
US-20060074113-A1 Thiadiazoline derivative KYOWA KIRIN CO., LTD. (JP) 2006-04-06 US claimed
EP-1454903-A1 THIADIAZOLINE DERIVATIVE KYOWA HAKKO KOGYO CO., LTD. (JP) 2004-09-08 EP claimed
EP-4393923-A1 PYRIDO RING COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATE, COMPOSITION, AND APPLICATION Yiyou Biotech (Shanghai) Co., Ltd. (CN) 2024-07-03 EP disclosed
CN-114213389-B Synthesis method of benzo [ b ] naphtho [2,3-d ] thiophene 棓诺(苏州)新材料有限公司 2024-01-09 CN disclosed
WO-2023230061-A2 SARS-COV-2 NSP14 METHYLTRANSFERASE INHIBITORS REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2023-11-30 WO disclosed
WO-2023115327-A1 PYRIDO RING COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATE, COMPOSITION, AND APPLICATION 中国药科大学 2023-06-29 WO disclosed
US-11655251-B2 Method for the production of lumateperone and its salts EGIS GYOGYSZERGYAR ZRT. (HU) 2023-05-23 US disclosed
EP-3464317-B1 AMINOSTEROID DERIVATIVES AND PROCESS FOR PRODUCING SAME UNIV LAVAL (CA) 2023-04-26 EP disclosed
US-20220396549-A1 SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEROF UNIV MARYLAND (US) 2022-12-15 US disclosed
CN-1675588-A Imaging material with purple laser photosensitive resist material layer and resist imaging method thereof MITSUBISHI CHEM CORP (JP) 2005-09-28 CN disclosed
CN-1651408-A Amino acid accelerated CuI catalyzed aryl halide and coupling reaction of alkyl sulfonate SHANGHAI INST ORGANIC CHEM (CN) 2005-08-10 CN disclosed
CN-1607461-A Resist polymer, resist composition and patterning process SHINETSU CHEMICAL CO (JP) 2005-04-20 CN disclosed
EP-1454903-A1 THIADIAZOLINE DERIVATIVE KYOWA HAKKO KOGYO CO., LTD. (JP) 2004-09-08 EP disclosed
US-6783912-B2 POSITIVE OR NEGATIVE AMPLIFICATION SHIPLEY COMPANY, L.L.C. 2004-08-31 US disclosed
WO-2004067522-A1 AZAPHENYLALANINE DERIVATIVES AND THEIR USE AS ANTITHROMBOTIC AGENTS LEK PHARMACEUTICALS D.D. (SI) 2004-08-12 WO disclosed
US-20020009663-A1 Photoacid generators and photoresists comprising same SHIPLEY COMPANY, L.L.C. 2002-01-24 US disclosed
WO-2001063363-A2 PHOTOACID GENERATORS AND PHOTORESISTS COMPRISING SAME SHIPLEY COMPANY, L.L.C. (US) 2001-08-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060074113-A1 Thiadiazoline derivative BRWD1, RB1, ARG2 ATM 516/4885LMNA 3970/4885L3MBTL1 88/4885
US-20220396549-A1 SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEROF MCL1, TP53, MYC ATM 1692/4885LMNA 2685/4885L3MBTL1 47/4885
US-11655251-B2 Method for the production of lumateperone and its salts CYP2S1, LSS, CYP26B1 ATM 4147/4885LMNA 677/4885L3MBTL1 2849/4885
US-20020009663-A1 Photoacid generators and photoresists comprising same GSS, TST, SQOR ATM 2464/4885LMNA 4492/4885L3MBTL1 4173/4885
US-20080207706-A1 THIADIAZOLINE DERIVATIVE BRWD1, RB1, ARG2 ATM 516/4885LMNA 3970/4885L3MBTL1 88/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.