Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.51 |
| ▸ | IDE | P14735 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7588756 | 0.88 | IDE (0.47) | HTR6IDECYP19A1ALKMEN1 | |
| SCHEMBL838015 | 0.80 | HTR6 (0.64) | HTR6IDECYP19A1ALKALOX5 | |
| SCHEMBL838017 | 0.80 | HTR6 (0.64) | HTR6IDECYP19A1ALKALOX5 | |
| SCHEMBL4932964 | 0.73 | NPC1 (0.58) | MEN1KMT2ACYP2C9HDAC1HDAC6 | |
| SCHEMBL4932973 | 0.73 | NPC1 (0.58) | MEN1KMT2ACYP2C9HDAC1HDAC6 | |
| SCHEMBL6545705 | 0.72 | IDE (0.55) | HTR6IDECYP19A1ALKALOX5 | |
| SCHEMBL946516 | 0.72 | HTR6 (0.74) | HTR6CYP19A1ALKALOX5PTGS2 | |
| SCHEMBL29169612 | 0.71 | HTR6 (0.64) | HTR6IDECYP19A1ALKALOX5 | |
| SCHEMBL850128 | 0.71 | ALOX5 (0.62) | HTR6CYP19A1ALKALOX5PTGS2 | |
| SCHEMBL3639382 | 0.70 | HTR6 (0.53) | HTR6CYP19A1ALKPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757984-B1 | Hydroxamic acid derivatives useful for inhibiting gelatinase | ONO PHARMACEUTICAL CO (JP) | 2002-10-30 | — | — | EP | claimed |
| US-6022893-A | PREVENTION AND TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION OR EXCESS ACTIVATION OF GELATINASES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-02-08 | — | — | US | claimed |
| EP-0757984-A1 | Hydroxamic acid derivatives useful for inhibiting gelatinase | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | claimed |
| EP-0757984-B1 | Hydroxamic acid derivatives useful for inhibiting gelatinase | ONO PHARMACEUTICAL CO (JP) | 2002-10-30 | — | — | EP | disclosed |
| US-6022893-A | PREVENTION AND TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION OR EXCESS ACTIVATION OF GELATINASES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-02-08 | — | — | US | disclosed |
| EP-0757984-A1 | Hydroxamic acid derivatives useful for inhibiting gelatinase | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |