SCHEMBL7584015

SCHEMBL7584015

O=C(O)C(=Cc1ccc(O)cc1)C(=O)C=Cc1ccc(O)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYR P14679 3/20 0.58
AKR1B10 O60218 2/20 0.58
AKR1B1 P15121 2/20 0.58
PKM P14618 2/20 0.58
CA12 O43570 2/20 0.58
CA1 P00915 2/20 0.58
CA2 P00918 2/20 0.58
CA7 P43166 2/20 0.58
CA9 Q16790 2/20 0.58
CA14 Q9ULX7 2/20 0.58
ESR1 P03372 1/20 0.58
CA3 P07451 1/20 0.58
CA4 P22748 1/20 0.58
CA6 P23280 1/20 0.58
DPP4 P27487 1/20 0.58
CA5A P35218 1/20 0.58
HCAR2 Q8TDS4 1/20 0.58
ESR2 Q92731 1/20 0.58
CA5B Q9Y2D0 1/20 0.58
F3 P13726 3/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11126196 0.85 MAPT (0.55) HCAR2F3CYP2D6CYP2C9MAOB
SCHEMBL1704759 0.82 ALDH1A1 (0.65) TYRAKR1B10AKR1B1PKMCA12
SCHEMBL27541702 0.81 KMT2A (0.54) HCAR2F3CYP2D6CYP2C9MAOB
SCHEMBL27623567 0.81 ALDH1A1 (0.60) TYRAKR1B10AKR1B1PKMCA12
SCHEMBL7598085 0.79 MMP1 (0.51) AKR1B10AKR1B1MAOBKDM4EALDH1A1
SCHEMBL7585198 0.78 HSD17B10 (0.62) AKR1B10AKR1B1CA12CA1CA2
SCHEMBL28435739 0.77 MAPT (0.59) HCAR2F3CYP2D6CYP2C9MAOB
SCHEMBL9416654 0.77 MAPT (0.59) HCAR2F3CYP2D6CYP2C9MAOB
SCHEMBL16670788 0.77 MMP1 (0.52) AKR1B10AKR1B1MAOBKDM4EGLO1
SCHEMBL9333787 0.76 MAPT (0.57) HCAR2F3CYP2D6CYP2C9MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3060574-A1 ALPHA BETA MODULATING PEPTIDES Alzhyme Pty Ltd (AU) 2016-08-31 EP disclosed
WO-2015058258-A1 AΒ MODULATING PEPTIDES ALZHYME PTY LTD (AU) 2015-04-30 WO disclosed
CN-1279053-C Modulators for beta-amyloid peptide aggregation comprising D-amino acids PRAECIS PHARM INC (US) 2006-10-11 CN disclosed
EP-1263454-A2 METHODS FOR ENHANCING THE BIOAVAILABILITY OF A DRUG Praecis Pharmaceuticals Incorporated (US) 2002-12-11 EP disclosed
WO-2000052048-A9 MODULATORS OF BETA-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS PRAECIS PHARM INC (US) 2002-04-11 WO disclosed
EP-1161449-A1 MODULATORS OF BETA-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS Praecis Pharmaceuticals Incorporated (US) 2001-12-12 EP disclosed
WO-2001058470-A2 METHODS FOR ENHANCING THE BIOAVAILABILITY OF A DRUG PRAECIS PHARMACEUTICALS INCORPORATED (US) 2001-08-16 WO disclosed
WO-2000052048-A1 MODULATORS OF BETA-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS PRAECIS PHARMACEUTICALS INCORPORATED (US) 2000-09-08 WO disclosed