Sugi Predict

Sugi Predict / Compounds / 1-Naphthol

1-Naphthol

1-Naphthol

SCHEMBL7584597

COc1ccc2cc(O)ccc2c1.Oc1cccc2ccccc12

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 5/20 0.55
▸ CYP2A6 P11509 1/20 0.55
▸ KMT2A Q03164 5/20 0.50
▸ MEN1 O00255 4/20 0.50
▸ CASP3 P42574 1/20 0.50
▸ SENP8 Q96LD8 1/20 0.50
▸ SENP7 Q9BQF6 1/20 0.50
▸ SENP6 Q9GZR1 1/20 0.50
▸ ABCG2 Q9UNQ0 3/20 0.48
▸ NPC1 O15118 2/20 0.47
▸ RAB9A P51151 2/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ TRPV1 Q8NER1 1/20 0.46
▸ LMNA P02545 2/20 0.45
▸ HIF1A Q16665 2/20 0.45
▸ PGR P06401 1/20 0.45
▸ CYP3A4 P08684 1/20 0.45
▸ ADORA3 P0DMS8 1/20 0.45
▸ AR P10275 1/20 0.45
▸ CHRM1 P11229 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1-Naphthol SCHEMBL2016852 0.90 CYP1A2 (0.63) CYP1A2CYP2A6KMT2AMEN1ABCG2
Betanaphthol SCHEMBL1240024 0.85 CYP1A2 (0.68) CYP1A2CYP3A4CYP2C19NQO2
Betanaphthol SCHEMBL10802368 0.85 CYP1A2 (0.76) CYP1A2CYP2A6KMT2AMEN1CASP3
SCHEMBL169434 0.83 MTNR1A (0.55) CYP1A2CYP2A6NQO2
SCHEMBL30277953 0.83 CYP1A2 (0.55) CYP1A2CYP2A6KMT2AMEN1NPC1
SCHEMBL774076 0.83 CYP1A2 (0.55) CYP1A2CYP2A6KMT2AMEN1NPC1
SCHEMBL28628067 0.82 CYP1A2 (0.70) CYP1A2CYP2A6KMT2AMEN1ABCG2
1-Naphthol SCHEMBL28321946 0.81 CYP1A2 (0.68) CYP1A2KMT2AMEN1NQO2
SCHEMBL547847 0.81 ABL1 (0.62) CYP1A2CYP2A6KMT2AMEN1CASP3
SCHEMBL31554258 0.81 ABL1 (0.62) CYP1A2CYP2A6KMT2AMEN1CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020156324-A1 BIPHENYL COMPOUNDS AND THEIR USE AS OESTROGENIC AGENTS AVENTIS PHARMA S.A. 2002-10-24 — — US disclosed
US-6448294-B1 SUCH AS 1,5-DICHORO- OR 5-(4-(2-(DIMETHYLAMINO)ETHOXY)PHENYL) SUBSTITUTED -6-(4-HYDROXYPHENYL)-2-NAPHTHALENOLS; ANTIUTERO-TROPHIC AND REPLACEMENT TREATMENT OF SYMPTOMS LINKED TO MENOPAUSE PARTICULARLY OSTEOPOROSIS AVENTIS PHARMA S.A. (FR) 2002-09-10 — — US disclosed
US-6365775-B1 ANTIUTEROTROPHIC; TREATMENTS OF SYMPTOMS RELATED TO MENOPAUSE AND PREMENSTRAL SYNDRONE AVENTIS PHARMA S.A. (FR) 2002-04-02 — — US disclosed
US-6147119-A TREATING HYPOFOLLICULINIA DISORDERS; ANTICARCINOGENIC, ANTIMETASTASIS AND ANTITUMOR AGENTS; PREMENSTRUAL TENSION, MENOPAUSE, OSTEOPOROSIS HOECHST MARION ROUSSEL (FR) 2000-11-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020156324-A1 BIPHENYL COMPOUNDS AND THEIR USE AS OESTROGENIC AGENTS SHBG, ESR2, CYP19A1 CYP1A2 65/4885CYP2A6 36/4885KMT2A 1973/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.