SCHEMBL774076

SCHEMBL774076

COc1ccc2c(O)cccc2c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.55
CYP2A6 P11509 1/20 0.55
PLAU P00749 1/20 0.53
HSD17B1 P14061 4/20 0.50
HSD17B2 P37059 4/20 0.50
ESR1 P03372 2/20 0.50
ESR2 Q92731 2/20 0.50
MTNR1A P48039 2/20 0.49
MTNR1B P49286 2/20 0.49
HDAC4 P56524 2/20 0.46
HDAC8 Q9BY41 2/20 0.46
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
NPC1 O15118 1/20 0.46
HSP90AA1 P07900 1/20 0.46
ECE2 P0DPD6 1/20 0.46
AGTR1 P30556 1/20 0.46
LMNA P02545 1/20 0.45
PGR P06401 1/20 0.45
CYP3A4 P08684 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30277953 1.00 CYP1A2 (0.55) CYP1A2CYP2A6PLAUHSD17B1HSD17B2
SCHEMBL3013825 0.86 HSD17B1 (0.67) PLAUHSD17B1HSD17B2ESR1ESR2
1-Naphthol SCHEMBL2016852 0.86 CYP1A2 (0.63) CYP1A2CYP2A6ESR1ESR2MTNR1A
SCHEMBL169434 0.85 MTNR1A (0.55) CYP1A2CYP2A6MTNR1AMTNR1B
1-Naphthol SCHEMBL7584597 0.83 CYP1A2 (0.55) CYP1A2CYP2A6MEN1KMT2ANPC1
SCHEMBL12722494 0.82 RAB9A (0.56) CYP1A2PLAUHSD17B1HSD17B2MTNR1A
SCHEMBL616200 0.81 CYP1A2 (0.55) CYP1A2CYP2A6MTNR1AMTNR1BMEN1
Mequinol SCHEMBL5528621 0.81 ESR2 (0.51) PLAUHSD17B1HSD17B2ESR1ESR2
SCHEMBL14686064 0.80 MAPT (0.51) CYP1A2PLAUHSD17B1HSD17B2ESR1
SCHEMBL26725170 0.80 PLAU (0.49) CYP1A2PLAUHSD17B1HSD17B2ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 221 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114369011-B New green method for preparing 2-diaryl methyl substituted-1-naphthol compound 湖南理工学院 2024-07-09 CN claimed
CN-116135848-A Coumarin compound and preparation method and application thereof 中国科学院兰州化学物理研究所 2023-05-19 CN claimed
CN-114369011-A Green novel method for preparing 2-diarylmethyl substituted-1-naphthol compound 湖南理工学院 2022-04-19 CN claimed
US-7211414-B2 Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity VISIGEN BIOTECHNOLOGIES, INC. (US) 2007-05-01 US claimed
EP-0697854-B1 USE OF HYDROXYNAPHTHALENES IN COLOURING AGENTS HENKEL KGAA (DE) 1997-03-05 EP claimed
EP-0697854-A1 USE OF HYDROXYNAPHTHALENES IN COLOURING AGENTS HENKEL KGAA (DE) 1996-02-28 EP claimed
WO-1994026241-A1 USE OF HYDROXYNAPHTHALENES IN COLOURING AGENTS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1994-11-24 WO claimed
US-4533766-A Process for the production of dihydroxybenzenes DEGUSSA AKTIENGESELLSCHAFT (DE) 1985-08-06 US claimed
US-12259386-B2 Method for co-diagnosis of ralstonia solanacearum and fusarium oxysporum by using semi-quantitative lateral flow immunodiagnostic technique and kit for use therein VETALL LABORATORIES (KR) 2025-03-25 US disclosed
CN-114369011-B New green method for preparing 2-diaryl methyl substituted-1-naphthol compound 湖南理工学院 2024-07-09 CN disclosed
CN-118063293-A Synthesis method of 6-methoxy-1-bromonaphthalene 山东邹平大展新材料有限公司 2024-05-24 CN disclosed
US-20240090329-A1 COMPOUND, ORGANIC ELECTROLUMINESCENT ELEMENT AND ELECTRONIC DEVICE IDEMITSU KOSAN CO.,LTD. (JP) 2024-03-14 US disclosed
CN-116135848-B Coumarin compound and preparation method and application thereof 中国科学院兰州化学物理研究所 2024-03-12 CN disclosed
EP-4153555-B1 PHOTOOXIDATION OF PHENOLIC COMPOUNDS DSM IP ASSETS BV (NL) 2024-01-31 EP disclosed
US-3980659-A INSECTICIDES, INTERMEDIATES FOR AZO DYES CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-09-14 US disclosed
US-3956294-A AZO DYES, PESTICIDES, ANALEPTICS, ANALGESICS, DIURETICS CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-05-11 US disclosed
US-3954782-A 2,6-Hydrazino-3-pyridine carboxyamides CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-05-04 US disclosed
US-3947463-A Certain 2-amino-nicotinonitrile derivatives CASSELLA FARBWERKE MAINKUR AG (DT) 1976-03-30 US disclosed
US-3946024-A INTERMEDIATES FOR AZO DYES CASSELLA FARBWERKE MAINKUR AG (DT) 1976-03-23 US disclosed
US-3935267-A CARDIOVASCULAR DISORDERS E. R. SQUIBB & SONS, INC. (US) 1976-01-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240090329-A1 COMPOUND, ORGANIC ELECTROLUMINESCENT ELEMENT AND ELECTRONIC DEVICE LEF1, SOX18, RPS19 CYP1A2 610/4885CYP2A6 1266/4885PLAU 4628/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.