Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL2228905 | 0.85 | TDP1 (0.48) | TDP1ALDH1A1TSHRMAPTKDM4E | |
| Propylene Glycol SCHEMBL3099019 | 0.83 | TDP1 (0.46) | TDP1ALDH1A1TSHRMAPTMEN1 | |
| Ethyl Propionate SCHEMBL303995 | 0.83 | MGAM (0.48) | TDP1ALDH1A1MAPTKDM4EDUSP3 | |
| SCHEMBL6563486 | 0.80 | — | — | |
| Alcohol SCHEMBL2831424 | 0.80 | ALDH1A1 (0.53) | TDP1ALDH1A1TSHRKMT2ALMNA | |
| Propylene Glycol SCHEMBL28409524 | 0.80 | NAAA (0.50) | TDP1ALDH1A1MAPTKDM4EDUSP3 | |
| SCHEMBL9276 | 0.80 | — | — | |
| Ethyl Propionate SCHEMBL104601 | 0.78 | MGAM (0.43) | TDP1ALDH1A1TSHRMAPTKDM4E | |
| Propylene Glycol SCHEMBL181936 | 0.78 | TDP1 (0.59) | TDP1ALDH1A1TSHROR51E2FFAR3 | |
| Propylene Glycol SCHEMBL5804824 | 0.78 | TDP1 (0.59) | TDP1ALDH1A1TSHROR51E2FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1232016-A1 | METHOD AND APPARATUS FOR DYNAMICALLY COATING A SUBSTRATE | PPG Industries Ohio, Inc. (US) | 2002-08-21 | — | — | EP | disclosed |
| WO-2001036108-A1 | METHOD AND APPARATUS FOR DYNAMICALLY COATING A SUBSTRATE | PPG INDUSTRIES OHIO, INC. (US) | 2001-05-25 | — | — | WO | disclosed |
| EP-0590033-A1 | POLYESTER-BASED COATING COMPOSITIONS HAVING HIGH PIGMENT-TO-BINDER RATIOS | EXXON CHEMICAL PATENTS INC. (US) | 1994-04-06 | — | — | EP | disclosed |