Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7582764 | 0.81 | DRD2 (0.38) | DRD2DRD3KDM4EALDH1A1MAPT | |
| SCHEMBL7590659 | 0.81 | TMEM97 (0.46) | MAPTSIGMAR1HTT | |
| SCHEMBL7586573 | 0.80 | KDM4E (0.36) | DRD4DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL7582141 | 0.79 | KDM4E (0.38) | DRD4DRD2DRD3KDM4ESIGMAR1 | |
| SCHEMBL7590671 | 0.78 | CHRNB2 (0.45) | DRD4DRD2DRD3SIGMAR1HTT | |
| SCHEMBL7581935 | 0.78 | KDM4E (0.40) | DRD4DRD2KDM4ELMNA | |
| SCHEMBL7581291 | 0.78 | KDM4E (0.40) | DRD4DRD2KDM4ELMNA | |
| SCHEMBL7581302 | 0.77 | SLC6A2 (0.33) | KDM4ESIGMAR1 | |
| SCHEMBL7584430 | 0.76 | CHRNA7 (0.47) | DRD2KDM4EALDH1A1MAPTSIGMAR1 | |
| SCHEMBL7955773 | 0.75 | SLC6A2 (0.34) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |