Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL969634 | 1.00 | DHFR (0.32) | DHFRGSK3BADKCNR1CNR2 | |
| Hydrochloric Acid SCHEMBL3356796 | 0.82 | DHFR (0.35) | DHFRGSK3BADK | |
| Hydrochloric Acid SCHEMBL8169188 | 0.82 | DHFR (0.32) | DHFR | |
| Hydrochloric Acid SCHEMBL219041 | 0.81 | HTR7 (0.34) | DHFRGSK3BADKCNR1CNR2 | |
| Hydrochloric Acid SCHEMBL218908 | 0.81 | HTR7 (0.36) | DHFRGSK3BADKCNR1CNR2 | |
| SCHEMBL7598615 | 0.80 | DHFR (0.32) | DHFR | |
| Hydrochloric Acid SCHEMBL622158 | 0.80 | DHFR (0.33) | DHFRGSK3BADK | |
| Hydrochloric Acid SCHEMBL7930461 | 0.77 | CHRNA1 (0.32) | DHFRGSK3BADK | |
| SCHEMBL797329 | 0.74 | TLR8 (0.32) | DHFRCNR2 | |
| Hydrochloric Acid SCHEMBL14775250 | 0.74 | SLC6A2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115730-B1 | CATALYTIC PROCESS FOR ISOMERIZING METALLOCENES | ALBEMARLE CORP (US) | 2002-10-02 | — | — | EP | disclosed |
| US-6337372-B1 | ADDITIOIN POLYMERIZATION OF OLEFINS AND PROPYLENE FOR BLOCK POLYMERS | CHISSO CORPORATION (JP) | 2002-01-08 | — | — | US | disclosed |
| EP-1115730-A1 | CATALYTIC PROCESS FOR ISOMERIZING METALLOCENES | ALBEMARLE CORPORATION (US) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017213-A1 | CATALYTIC PROCESS FOR ISOMERIZING METALLOCENES | ALBEMARLE CORPORATION (US) | 2000-03-30 | — | — | WO | disclosed |
| US-5965759-A | Catalytic process for isomerizing metallocenes | ALBEMARLE CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |