Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 known ✓ | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG known ✓ | P07510 | 1/20 | 0.32 |
| ▸ | CHRNB1 known ✓ | P11230 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | CHRND known ✓ | Q07001 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | ADK | P55263 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14775250 | 0.80 | SLC6A2 (0.34) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| Hydrochloric Acid SCHEMBL219041 | 0.78 | HTR7 (0.34) | SLC6A2SLC6A4SLC6A3DHFRGSK3B | |
| Hydrochloric Acid SCHEMBL218908 | 0.78 | HTR7 (0.36) | SLC6A2SLC6A4SLC6A3DHFRGSK3B | |
| Hydrochloric Acid SCHEMBL969634 | 0.77 | DHFR (0.32) | DHFRGSK3BADK | |
| Hydrochloric Acid SCHEMBL7586032 | 0.77 | DHFR (0.32) | DHFRGSK3BADK | |
| Hydrochloric Acid SCHEMBL7921149 | 0.75 | ALDH1A1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL5616525 | 0.70 | DHFR (0.35) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| Hydrochloric Acid SCHEMBL622158 | 0.69 | DHFR (0.33) | DHFRGSK3BADK | |
| Hydrochloric Acid SCHEMBL7929752 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL8158808 | 0.68 | HTR1A (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153938-A1 | CATALYST FOR STEREOREGULAR POLYMERIZATION OF ALPHA-OLEFIN AND PROCESS FOR PRODUCING STEREOREGULAR ALPHA-OLEFIN POLYMER | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-11-14 | — | — | EP | disclosed |