Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.58 |
| ▸ | CDK7 | P50613 | 4/20 | 0.57 |
| ▸ | FADS1 | O60427 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 4/20 | 0.53 |
| ▸ | CDC7 | O00311 | 3/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.53 |
| ▸ | PAK4 | O96013 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | CLK2 | P49760 | 3/20 | 0.53 |
| ▸ | PRKX | P51817 | 3/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.53 |
| ▸ | MELK | Q14680 | 3/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.53 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.53 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18812669 | 0.80 | HDAC6 (0.57) | HDAC6CDK7FLT3CDK2MAPT | |
| SCHEMBL1461452 | 0.78 | HDAC6 (0.75) | HDAC6FGFR1GSK3B | |
| SCHEMBL628194 | 0.78 | HDAC6 (0.64) | HDAC6CDK7FLT3CDC7DAPK3 | |
| SCHEMBL4448025 | 0.76 | CDK7 (0.62) | HDAC6CDK7FLT3CDC7DAPK3 | |
| SCHEMBL4738870 | 0.76 | FADS1 (0.55) | FADS1CDC7CDK5KDRGSK3A | |
| SCHEMBL758654 | 0.76 | CDK7 (0.58) | HDAC6CDK7FLT3CDC7DAPK3 | |
| SCHEMBL2480608 | 0.76 | FLT3 (0.59) | CDK7FLT3CDC7DAPK3PAK4 | |
| SCHEMBL2482107 | 0.76 | FLT3 (0.59) | CDK7FLT3CDC7DAPK3PAK4 | |
| SCHEMBL1179557 | 0.76 | CDK7 (0.59) | HDAC6CDK7FLT3CDC7DAPK3 | |
| SCHEMBL2411577 | 0.76 | RAB9A (0.49) | HDAC6FLT3PDGFRBFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089307-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | claimed |
| US-20240216316-A1 | DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC | BUCK INST RES AGING (US) | 2024-07-04 | — | — | US | disclosed |
| US-20080200458-A1 | Methods and compositions for the treatment of body composition disorders | LEXICON PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | disclosed |
| US-20080194557-A1 | Methods and compositions for the treatment of pain, inflammation and cancer | LEXICON PHARMACEUTICALS, INC. | 2008-08-14 | — | — | US | disclosed |
| WO-2008089307-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194557-A1 | Methods and compositions for the treatment of pain, inflammation and cancer | TNF, IL6, CXCL8 | HDAC6 301/4885CDK7 2490/4885FADS1 1059/4885 |
| US-20240216316-A1 | DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC | DAGLA, DAGLB, MGLL | HDAC6 3958/4885CDK7 2224/4885FADS1 192/4885 |
| US-20080200458-A1 | Methods and compositions for the treatment of body composition disorders | CPT1B, CPT1A, SHBG | HDAC6 1405/4885CDK7 3545/4885FADS1 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.