Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 6/20 | 0.39 |
| ▸ | HTR6 | P50406 | 6/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7581561 | 0.86 | APAF1 (0.44) | MITFAPAF1HTR6CHRNA7DRD3 | |
| SCHEMBL7585774 | 0.85 | CHRNA7 (0.43) | MITFAPAF1HTR6CHRNA7HTR1A | |
| SCHEMBL7583617 | 0.85 | CHRNA7 (0.40) | MITFAPAF1HTR6CHRNA7HTR1A | |
| SCHEMBL7584062 | 0.82 | GAA (0.43) | MITFAPAF1HTR6CHRNA7GAA | |
| SCHEMBL7583056 | 0.82 | SMN1; SMN2 (0.41) | MITFCHRNA7GAAPOLBDRD3 | |
| SCHEMBL8629280 | 0.78 | MITF (0.41) | MITFAPAF1HTR6CHRNA7HTR1A | |
| SCHEMBL8627347 | 0.78 | MITF (0.39) | MITFAPAF1CHRNA7GAADRD3 | |
| Hydrochloric Acid SCHEMBL8625633 | 0.77 | BRD4 (0.38) | MITFAPAF1CHRNA7GAADRD3 | |
| SCHEMBL8630282 | 0.77 | PGAM1 (0.39) | MITFAPAF1CHRNA7DRD3HRH3 | |
| SCHEMBL7583496 | 0.76 | GAA (0.52) | CHRNA7HTR1AGAAGFERRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |