SCHEMBL7587368

SCHEMBL7587368

NCc1nn(-c2ccccc2)c(=O)c2ccccc12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCAT1 P54687 1/20 0.55
GAA P10253 2/20 0.51
NPSR1 Q6W5P4 2/20 0.51
ALDH1A1 P00352 4/20 0.49
ADORA3 P0DMS8 3/20 0.49
MAPT P10636 1/20 0.48
MAPK1 P28482 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
ENPP1 P22413 1/20 0.47
HTT P42858 1/20 0.47
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
AURKA O14965 1/20 0.46
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA9 Q16790 1/20 0.46
PRMT5 O14744 1/20 0.45
LMNA P02545 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6237284 0.85 ALDH1A1 (0.67) BCAT1GAANPSR1ALDH1A1ADORA3
SCHEMBL28917160 0.81 ALDH1A1 (0.56) BCAT1GAANPSR1ALDH1A1ADORA3
SCHEMBL24000702 0.77 NPSR1 (0.68) BCAT1GAANPSR1ALDH1A1MAPT
Hydrochloric Acid SCHEMBL7425536 0.77 RARG (0.46) GAAALDH1A1MAPTMAPK1L3MBTL1
SCHEMBL14917566 0.75 RAB9A (0.76) BCAT1GAANPSR1ALDH1A1MAPK1
SCHEMBL4060721 0.75 BCAT1 (0.58) BCAT1GAANPSR1ALDH1A1ADORA3
SCHEMBL9231347 0.74 NPSR1 (0.79) BCAT1GAANPSR1ALDH1A1MAPT
SCHEMBL30719634 0.74 NPSR1 (0.79) BCAT1GAANPSR1ALDH1A1MAPT
SCHEMBL14518042 0.70 ALDH1A1 (0.59) BCAT1NPSR1ALDH1A1ADORA3MAPK1
SCHEMBL15731746 0.69 GAA (0.51) GAANPSR1ALDH1A1MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1231982-A2 USE OF PHTHALAZINE DERIVATIVES BASF AKTIENGESELLSCHAFT (DE) 2002-08-21 EP disclosed
WO-2001082877-A2 USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS BASF AKTIENGESELLSCHAFT (DE) 2001-11-08 WO disclosed
WO-2000067734-A2 USE OF PHTHALAZINE DERIVATIVES BASF AKTIENGESELLSCHAFT (DE) 2000-11-16 WO disclosed