Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7587363 | 0.88 | NPC1 (0.55) | NPC1RAB9AMITFPKMALDH1A1 | |
| SCHEMBL7589532 | 0.88 | NPC1 (0.50) | NPC1RAB9AMITFPKMALDH1A1 | |
| SCHEMBL7586791 | 0.84 | NPBWR1 (0.48) | NPC1RAB9AMITFPKMKMT2A | |
| SCHEMBL7588481 | 0.83 | NPC1 (0.47) | NPC1RAB9AMITFPKMALDH1A1 | |
| SCHEMBL7586423 | 0.83 | NPC1 (0.55) | NPC1RAB9AMITFPKMALDH1A1 | |
| SCHEMBL7590779 | 0.80 | AKR1B1 (0.45) | NPC1RAB9AMITFPKMKMT2A | |
| SCHEMBL7761997 | 0.79 | ALOX5 (0.43) | NPC1RAB9AMITFPKMALDH1A1 | |
| SCHEMBL7759225 | 0.76 | GAA (0.44) | NPC1RAB9AMITFPKMALDH1A1 | |
| SCHEMBL7587105 | 0.73 | MAPT (0.48) | NPC1RAB9AMITFPKMKMT2A | |
| SCHEMBL7591588 | 0.70 | NPC1 (0.44) | NPC1RAB9AMITFPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1231982-A2 | USE OF PHTHALAZINE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2002-08-21 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |
| WO-2000067734-A2 | USE OF PHTHALAZINE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |