Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7587363 | 0.89 | NPC1 (0.55) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL7586423 | 0.86 | NPC1 (0.55) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL7590779 | 0.83 | AKR1B1 (0.45) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL7589532 | 0.83 | NPC1 (0.50) | NPC1RAB9AMITFPKMRPS6KA2 | |
| SCHEMBL7587542 | 0.83 | NPC1 (0.56) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL7761997 | 0.82 | ALOX5 (0.43) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL7586791 | 0.80 | NPBWR1 (0.48) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL7759225 | 0.79 | GAA (0.44) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL7587105 | 0.76 | MAPT (0.48) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL10940866 | 0.75 | NPC1 (0.57) | NPC1RAB9AMITFPKMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1231982-A2 | USE OF PHTHALAZINE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2002-08-21 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |
| WO-2000067734-A2 | USE OF PHTHALAZINE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |