Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570508 | 0.77 | TSHR (0.64) | TSHRLMNAALDH1A1HTTTP53 | |
| SCHEMBL28677113 | 0.72 | TP53 (0.53) | TSHRLMNAALDH1A1TP53HPGD | |
| SCHEMBL7573883 | 0.70 | KMT2A (0.64) | TSHRLMNAALDH1A1HTTTP53 | |
| SCHEMBL7593518 | 0.70 | ACLY (0.61) | CYP2C9TDP1ACLY | |
| SCHEMBL38652788 | 0.68 | TP53 (0.55) | LMNAALDH1A1HTTTP53SMN1; SMN2 | |
| SCHEMBL12201314 | 0.68 | METAP2 (0.61) | LMNAALDH1A1HTTHPGDKMT2A | |
| SCHEMBL12201985 | 0.68 | KMT2A (0.56) | TSHRLMNAALDH1A1HTTTP53 | |
| SCHEMBL7572290 | 0.66 | LMNA (0.72) | TSHRLMNAALDH1A1HTTTP53 | |
| SCHEMBL7149263 | 0.66 | MAPT (0.58) | LMNAALDH1A1HTTHPGDSMN1; SMN2 | |
| SCHEMBL7594909 | 0.66 | NPC1 (0.89) | TSHRLMNAALDH1A1HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |