Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.59 |
| ▸ | EDNRB | P24530 | 2/20 | 0.56 |
| ▸ | EDNRA | P25101 | 2/20 | 0.56 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CCR4 | P51679 | 2/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7588981 | 0.82 | ALDH1A1 (0.64) | LMNAMEN1KMT2AALDH1A1HTT | |
| SCHEMBL14433894 | 0.82 | TSHR (0.52) | CCR2EDNRBEDNRAPTGES2LMNA | |
| SCHEMBL7595588 | 0.80 | CCR2 (0.65) | CCR2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL7590523 | 0.80 | LMNA (0.69) | LMNAMEN1KMT2AALDH1A1HTT | |
| SCHEMBL7594352 | 0.79 | HSD17B2 (0.52) | CCR2PTGES2LMNAMEN1KMT2A | |
| SCHEMBL7578178 | 0.79 | PTGES2 (0.64) | CCR2PTGES2LMNAMEN1KMT2A | |
| SCHEMBL1259968 | 0.79 | HSD17B2 (0.67) | CCR2EDNRBEDNRAPTGES2LMNA | |
| SCHEMBL15479178 | 0.79 | CCR2 (0.75) | CCR2LMNAMEN1KMT2AHTT | |
| SCHEMBL9931199 | 0.78 | CCR2 (0.57) | CCR2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL9930526 | 0.77 | CCR2 (0.81) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |