Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
| ▸ | TNKS | O95271 | 1/20 | 0.30 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18294767 | 0.91 | RORC (0.31) | — | |
| SCHEMBL7581116 | 0.88 | TP53 (0.31) | — | |
| SCHEMBL7589827 | 0.87 | P2RX7 (0.34) | — | |
| SCHEMBL7582511 | 0.86 | TNKS2 (0.35) | NR1H3TNKSTNKS2PARP3 | |
| SCHEMBL7579035 | 0.86 | TNKS2 (0.35) | NR1H3TNKSTNKS2PARP3 | |
| SCHEMBL13054282 | 0.86 | TNKS2 (0.35) | NR1H3TNKSTNKS2PARP3 | |
| SCHEMBL7589834 | 0.85 | KIF11 (0.38) | — | |
| SCHEMBL7589846 | 0.85 | — | — | |
| SCHEMBL7589861 | 0.81 | — | — | |
| SCHEMBL7585494 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183252-B2 | Heterocyclic aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2012-05-22 | — | — | US | disclosed |