Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.45 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7591224 | 0.84 | KDM4E (0.52) | NPC1RAB9AALDH1A1TSHRPIK3CA | |
| SCHEMBL28680201 | 0.79 | TSHR (0.50) | BRD4OPRM1OPRD1OGFRL1NPC1 | |
| SCHEMBL6302571 | 0.79 | TSHR (0.50) | BRD4OPRM1OPRD1OGFRL1NPC1 | |
| SCHEMBL7587674 | 0.77 | RAB9A (0.64) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL32671905 | 0.74 | TSHR (0.55) | BRD4OPRM1OPRD1OGFRL1NPC1 | |
| SCHEMBL30473266 | 0.74 | BRD4 (0.48) | BRD4OPRM1OPRD1OGFRL1NPC1 | |
| SCHEMBL8861190 | 0.72 | OPRM1 (0.58) | BRD4OPRM1OPRD1OGFRL1NPC1 | |
| SCHEMBL7590443 | 0.72 | MKNK2 (0.58) | — | |
| SCHEMBL7587224 | 0.71 | KDM4E (0.43) | RAB9AALDH1A1POLBKDM4EHSD17B10 | |
| SCHEMBL1029793 | 0.70 | KDM4E (0.49) | NPC1RAB9AGAAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206260-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-1206260-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000207-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |