Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 3/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL299875 | 0.86 | KDM1A (0.39) | KDM1AGPR119MPOHDAC1HDAC6 | |
| SCHEMBL758592 | 0.84 | HDAC1 (0.44) | KDM1AGPR119MPOHDAC1HDAC6 | |
| SCHEMBL288301 | 0.82 | KDM4A (0.38) | CNR2IDO1KCNH2 | |
| SCHEMBL29173113 | 0.81 | KDM1A (0.43) | KDM1AGPR119MPOHDAC1HDAC6 | |
| SCHEMBL22397607 | 0.80 | UCHL1 (0.40) | KDM1AGPR119MPOHDAC1HDAC6 | |
| SCHEMBL27061519 | 0.80 | MPO (0.44) | KDM1AGPR119MPOHDAC1HDAC6 | |
| SCHEMBL13568076 | 0.80 | ESR2 (0.47) | GPR119MAPTGRM5 | |
| SCHEMBL22397739 | 0.79 | MPO (0.42) | KDM1AGPR119MPOHDAC1HDAC6 | |
| SCHEMBL27437947 | 0.79 | CHRM4 (0.40) | KDM1AGPR119MPOHDAC1HDAC6 | |
| SCHEMBL20572183 | 0.77 | IDO1 (0.44) | KDM1AGPR119MPOHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120052130-A1 | GPR 119 MODULATORS | PFIZER INC. | 2012-03-01 | — | — | US | disclosed |
| US-20100285145-A1 | GPR 119 MODULATORS | PFIZER INC | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120052130-A1 | GPR 119 MODULATORS | GPR119, GPR39, GPR65 | KDM1A 3691/4885GPR119 1/4885CNR2 199/4885 |
| US-20100285145-A1 | GPR 119 MODULATORS | GPR119, GPR65, GPR39 | KDM1A 3574/4885GPR119 1/4885CNR2 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.