Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7592521 | 0.90 | LMNA (0.75) | LMNASMN1; SMN2HPGDPOLBALDH1A1 | |
| SCHEMBL9968019 | 0.83 | LMNA (0.84) | LMNASMN1; SMN2HPGDPOLBALDH1A1 | |
| SCHEMBL8659289 | 0.82 | LMNA (0.54) | LMNASMN1; SMN2HPGDPOLBTDP1 | |
| SCHEMBL7595414 | 0.79 | ALDH1A1 (0.70) | LMNAPOLBALDH1A1MAPTL3MBTL1 | |
| SCHEMBL25590005 | 0.78 | KEAP1 (0.60) | LMNASMN1; SMN2HPGDPOLBTDP1 | |
| SCHEMBL7580401 | 0.78 | CA1 (0.70) | LMNASMN1; SMN2POLBALDH1A1MAPT | |
| SCHEMBL8660042 | 0.77 | HPGD (0.53) | LMNASMN1; SMN2HPGDPOLBTDP1 | |
| SCHEMBL7588784 | 0.76 | ALDH1A1 (0.59) | LMNAPOLBALDH1A1MAPTL3MBTL1 | |
| SCHEMBL2367811 | 0.76 | APP (0.62) | LMNAPOLBALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5956125 | 0.76 | ALDH1A1 (0.59) | LMNAPOLBALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |