Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | MMP1 | P03956 | 1/20 | 0.59 |
| ▸ | MMP2 | P08253 | 1/20 | 0.59 |
| ▸ | MMP9 | P14780 | 1/20 | 0.59 |
| ▸ | MMP8 | P22894 | 1/20 | 0.59 |
| ▸ | MMP13 | P45452 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | IDO1 | P14902 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7574036 | 0.87 | PKM (0.68) | PKMLMNAHTTSMN1; SMN2IDO1 | |
| SCHEMBL5595046 | 0.83 | HTT (0.60) | LMNAHTTSMN1; SMN2KDM4ETSHR | |
| SCHEMBL7591363 | 0.80 | CA1 (0.66) | LMNACA1CA2SMN1; SMN2ALDH1A1 | |
| SCHEMBL7837467 | 0.79 | LMNA (0.63) | PKMLMNACA1CA2MMP1 | |
| SCHEMBL4251593 | 0.77 | IDO1 (0.77) | PKMLMNACA1CA2HTT | |
| SCHEMBL17103022 | 0.77 | KMT2A (0.67) | LMNAHTTSMN1; SMN2IDO1KDM4E | |
| SCHEMBL11887610 | 0.77 | MAPK1 (0.70) | PKMLMNAHTTSMN1; SMN2IDO1 | |
| SCHEMBL5956125 | 0.77 | ALDH1A1 (0.59) | LMNACA1CA2HTTALDH1A1 | |
| SCHEMBL7589388 | 0.77 | CCR2 (0.54) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL6351422 | 0.77 | HTT (0.67) | LMNAHTTSMN1; SMN2TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |