Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818117 | 0.85 | SIRT2 (0.44) | SIRT2KDM4ENPC1MAPTNFKB1 | |
| SCHEMBL7844409 | 0.84 | ALOX5 (0.52) | SIRT2CA12CA1CA9NPC1 | |
| SCHEMBL1097103 | 0.81 | SIRT2 (0.42) | SIRT2MAPTNFKB1RAB9ASMN1; SMN2 | |
| SCHEMBL7831405 | 0.79 | SIRT2 (0.35) | SIRT2KDM4EMAPTALOX5AP | |
| SCHEMBL6674214 | 0.78 | KCNH2 (0.46) | SIRT2 | |
| SCHEMBL7597443 | 0.77 | MAOA (0.39) | SIRT2CA12CA9 | |
| SCHEMBL7260656 | 0.77 | CA12 (0.36) | SIRT2CA12CA1CA9 | |
| SCHEMBL4024513 | 0.77 | CA12 (0.38) | SIRT2CA12CA1CA9KDM4E | |
| SCHEMBL8543176 | 0.77 | SIRT2 (0.40) | SIRT2MAPTNFKB1RAB9ASMN1; SMN2 | |
| SCHEMBL7939506 | 0.76 | SIRT2 (0.40) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222174-A1 | IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE | Takeda Chemical Industries, Ltd. (JP) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001030762-A1 | IMIDAZOL-4-YLMETHANOLS USE AS INHIBITORS OF STEROID C17-20 LYASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-03 | — | — | WO | disclosed |