Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818117 | 0.89 | SIRT2 (0.44) | NPC1RAB9ASIRT2MAOB | |
| SCHEMBL224236 | 0.84 | SIRT2 (0.43) | SIRT2 | |
| SCHEMBL7594682 | 0.84 | SIRT2 (0.41) | NPC1RAB9ASIRT2CA12CA1 | |
| SCHEMBL6674214 | 0.84 | KCNH2 (0.46) | SIRT2 | |
| SCHEMBL7597443 | 0.81 | MAOA (0.39) | MRGPRX4SIRT2CA12MAOAMAOB | |
| SCHEMBL5203299 | 0.80 | MAOB (0.50) | CYP3A4SIRT2MAOB | |
| SCHEMBL5751662 | 0.80 | ALOX5 (0.44) | ALOX5CYP3A4NPC1RAB9AMEN1 | |
| SCHEMBL5750032 | 0.80 | ALOX5 (0.44) | ALOX5NPC1MEN1KMT2AMRGPRX4 | |
| SCHEMBL7384162 | 0.79 | ALDH1A1 (0.53) | RAB9AMEN1KMT2ASIRT2 | |
| SCHEMBL5747790 | 0.78 | ALOX5 (0.45) | ALOX5CYP3A4NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073640-A1 | NAPHTHALENE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999054309-A1 | NAPHTHALENE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-28 | — | — | WO | disclosed |