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SCHEMBL7595616

SCHEMBL7595616

Cc1ccc(S(=O)(=O)Nc2ccc(F)c(F)c2)cc1.O=S(=O)(Nc1cc(Br)c(Br)cc1NS(=O)(=O)c1ccc(Br)cc1)c1ccc(Br)cc1.O=S(=O)(Nc1cc(Br)c(Br)cc1NS(=O)(=O)c1ccc(F)cc1)c1ccc(F)cc1

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 6/20 0.51
▸ MEN1 O00255 5/20 0.51
▸ MAPT P10636 5/20 0.51
▸ TP53 P04637 4/20 0.46
▸ LMNA P02545 4/20 0.46
▸ HTT P42858 2/20 0.46
▸ METAP2 P50579 1/20 0.46
▸ CA1 P00915 1/20 0.45
▸ CA2 P00918 1/20 0.45
▸ FFAR4 Q5NUL3 1/20 0.44
▸ ALDH1A1 P00352 1/20 0.44
▸ THRB P10828 1/20 0.44
▸ CYP2C9 P11712 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7574073 0.80 CA1 (0.62) KMT2AMEN1MAPTTP53LMNA
SCHEMBL5956125 0.78 ALDH1A1 (0.59) MAPTLMNAHTTMETAP2CA1
SCHEMBL7595505 0.78 KEAP1 (0.59) KMT2AMEN1CA1CA2FFAR4
SCHEMBL30111107 0.76 METAP2 (0.60) KMT2AMEN1MAPTLMNAHTT
SCHEMBL3367872 0.75 MEN1 (0.73) KMT2AMEN1MAPTTP53LMNA
SCHEMBL3919353 0.75 CA1 (0.69) KMT2AMEN1MAPTLMNAHTT
SCHEMBL6831830 0.75 CA12 (0.68) KMT2AMEN1MAPTLMNAHTT
SCHEMBL7588784 0.75 ALDH1A1 (0.59) MAPTLMNAHTTCA1CA2
SCHEMBL2831972 0.75 CA12 (0.68) KMT2AMEN1MAPTLMNAHTT
SCHEMBL6555446 0.75 MEN1 (0.73) KMT2AMEN1MAPTTP53LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1239852-A2 BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS Arrow Therapeutics Limited (GB) 2002-09-18 — — EP disclosed
WO-2001028537-A2 BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS ARROW THERAPEUTICS LIMITED (GB) 2001-04-26 — — WO disclosed