Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.39 |
| ▸ | FABP7 | O15540 | 1/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7598057 | 0.82 | ACHE (0.40) | MTNR1AMTNR1BCA1CA2CA12 | |
| SCHEMBL9219110 | 0.81 | FABP5 (0.43) | MTNR1AMTNR1BCA1CA2CA12 | |
| SCHEMBL9209684 | 0.78 | NOTUM (0.38) | AADATMAPT | |
| SCHEMBL9763023 | 0.77 | CYP1A2 (0.46) | MTNR1AMTNR1BCA1CA2CA12 | |
| SCHEMBL12061369 | 0.77 | CA1 (0.42) | MTNR1AMTNR1BCA1CA2CA12 | |
| SCHEMBL25604626 | 0.76 | EPHX2 (0.54) | MTNR1AMTNR1BCA1CA2EPHX2 | |
| Hydrochloric Acid SCHEMBL7596657 | 0.75 | DRD2 (0.51) | AADAT | |
| SCHEMBL7596840 | 0.74 | MTNR1A (0.60) | MTNR1AMTNR1BCA1CA2CYP1A2 | |
| SCHEMBL8605995 | 0.72 | MTNR1A (0.61) | MTNR1AMTNR1BCA1CA2EPHX2 | |
| SCHEMBL7778584 | 0.72 | MTNR1A (0.61) | MTNR1AMTNR1BCA1CA2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781280-B1 | DERIVATIVES OF BENZOPYRAN AND OF BENZOTHIOPYRAN, THEIR PREPARATION AND THEIR USE AS AGONISTS OF DOPAMINERGIC RECEPTORS | ZAMBON SPA (IT) | 2002-11-06 | — | — | EP | disclosed |
| EP-0389425-B1 | Benzotiopyranyl amines | CIBA GEIGY AG (CH) | 1995-04-26 | — | — | EP | disclosed |
| US-5071858-A | Antipsychotic benzothiopyranylamines | CIBA-GEIGY CORPORATION (US) | 1991-12-10 | — | — | US | disclosed |
| US-4992465-A | Antidepressant, anxiolytic agents; treating central nervous system disorders | CIBA-GEIGY CORPORATION (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0389425-A1 | Benzotiopyranyl amines | CIBA-GEIGY AG (CH) | 1990-09-26 | — | — | EP | disclosed |
| US-4801605-A | ANTIDEPRESSANT, NERVOUS SYSTEM DISORDERS, SEROTONIC ANTAGONIST | CIBA-GEIGY CORPORATION (US) | 1989-01-31 | — | — | US | disclosed |
| US-4721787-A | CONDENSATION, REDUCTION, DEHYDRATION | CIBA-GEIGY CORPORATION (US) | 1988-01-26 | — | — | US | disclosed |
| US-4604397-A | Certain benzo-(pyrano and thiopyrano)-pyridines, useful as CNS agents | CIBA-GEIGY CORPORATION (US) | 1986-08-05 | — | — | US | disclosed |