SCHEMBL7597428

SCHEMBL7597428

Cc1cccc(Oc2ccc(C(F)(F)F)cc2Cl)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.51
NPSR1 Q6W5P4 2/20 0.51
MAPT P10636 1/20 0.51
FFAR1 O14842 3/20 0.48
MEN1 O00255 1/20 0.47
TTR P02766 1/20 0.47
PPOX P50336 1/20 0.47
KMT2A Q03164 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
HTR2A P28223 4/20 0.46
SLC6A4 P31645 4/20 0.46
KCNH2 Q12809 4/20 0.46
ALDH1A1 P00352 1/20 0.45
GAA P10253 1/20 0.45
MRGPRX4 Q96LA9 2/20 0.45
STK39 Q9UEW8 1/20 0.45
EGFR P00533 1/20 0.44
ERBB2 P04626 1/20 0.44
ERBB3 P21860 1/20 0.44
ERBB4 Q15303 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10538095 0.89 NPSR1 (0.57) L3MBTL1NPSR1MAPTFFAR1MEN1
SCHEMBL25917913 0.88 STK39 (0.50) L3MBTL1NPSR1MAPTFFAR1MEN1
SCHEMBL11109866 0.88 HTR2A (0.49) L3MBTL1NPSR1MAPTHTR2ASLC6A4
SCHEMBL11046440 0.85 L3MBTL1 (0.70) L3MBTL1NPSR1MAPTFFAR1MEN1
SCHEMBL11648951 0.85 FFAR1 (0.50) L3MBTL1NPSR1MAPTFFAR1MEN1
SCHEMBL9132379 0.84 FFAR1 (0.49) L3MBTL1NPSR1MAPTFFAR1MEN1
SCHEMBL15384989 0.83 HTR2A (0.59) L3MBTL1MAPTFFAR1MEN1TTR
SCHEMBL9003844 0.83 FFAR1 (0.60) L3MBTL1NPSR1MAPTFFAR1MEN1
SCHEMBL8813323 0.82 MRGPRX4 (0.61) L3MBTL1NPSR1MAPTFFAR1MEN1
SCHEMBL14018271 0.82 FFAR1 (0.48) L3MBTL1NPSR1MAPTFFAR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0971875-B1 PROCESS FOR THE PURIFICATION OF SUBSTITUTED P-NITRODIPHENYLETHERS SYNGENTA LTD (GB) 2002-11-27 EP claimed
US-6072080-A DISSOLVING MIXTURE IN CRYSTALLIZING SOLVENT, WASHING SOLUTION WITH AQUEOUS ACIDIC SOLUTION, RECRYSTALLIZING ZENECA LIMITED (GB) 2000-06-06 US claimed
EP-0971875-A1 PROCESS FOR THE PURIFICATION OF SUBSTITUTED P-NITRODIPHENYLETHERS ZENECA LIMITED (GB) 2000-01-19 EP claimed
US-5910604-A NITROPHENYL ETHERS, ESPECIALLY ACIFLUORFEN ZENECA LIMITED (GB) 1999-06-08 US claimed
WO-1998040347-A1 PROCESS FOR THE PURIFICATION OF SUBSTITUTED P-NITRODIPHENYLETHERS ZENECA LIMITED (GB) 1998-09-17 WO claimed
US-4503245-A Solvent and catalyst recovery and recycle in the manufacture of phenoxybenzoic acid derivatives RHONE-POULENC, INC. (US) 1985-03-05 US claimed
US-4485254-A Process for preparing phenoxybenzoic acids ROHM AND HAAS COMPANY (US) 1984-11-27 US claimed
US-4484008-A SOLVENT EXTRACTION WITH WATER AND SEPARATION PPG INDUSTRIES, INC. (US) 1984-11-20 US claimed
US-4456767-A Solvent and catalyst recovery and recycle in the manufacture of phenoxybenzoic acid RHONE-POULENC, INC. (US) 1984-06-26 US claimed
EP-0971875-B1 PROCESS FOR THE PURIFICATION OF SUBSTITUTED P-NITRODIPHENYLETHERS SYNGENTA LTD (GB) 2002-11-27 EP disclosed
US-6072080-A DISSOLVING MIXTURE IN CRYSTALLIZING SOLVENT, WASHING SOLUTION WITH AQUEOUS ACIDIC SOLUTION, RECRYSTALLIZING ZENECA LIMITED (GB) 2000-06-06 US disclosed
EP-0971875-A1 PROCESS FOR THE PURIFICATION OF SUBSTITUTED P-NITRODIPHENYLETHERS ZENECA LIMITED (GB) 2000-01-19 EP disclosed
US-5910604-A NITROPHENYL ETHERS, ESPECIALLY ACIFLUORFEN ZENECA LIMITED (GB) 1999-06-08 US disclosed
WO-1998040347-A1 PROCESS FOR THE PURIFICATION OF SUBSTITUTED P-NITRODIPHENYLETHERS ZENECA LIMITED (GB) 1998-09-17 WO disclosed
US-4424393-A Process of preparation of substituted diphenyl ethers PPG INDUSTRIES, INC. (US) 1984-01-03 US disclosed
US-4401828-A Process for preparing phenoxybenzoic acids ROHM AND HAAS COMPANY (US) 1983-08-30 US disclosed
EP-0056119-A1 Substituted diphenyl ethers, herbicides containing them and their use as herbicides BASF Aktiengesellschaft (DE) 1982-07-21 EP disclosed
US-4323692-A Process for preparing phenoxybenzoic acids ROHM AND HAAS COMPANY (US) 1982-04-06 US disclosed
EP-0034413-A1 Process for the preparation of diphenylether carboxylic acids IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-08-26 EP disclosed
EP-0022610-A1 Process for preparing 2-nitro-5-(substituted-phenoxy) benzoic acids and salts thereof RHONE-POULENC AGROCHIMIE (FR) 1981-01-21 EP disclosed