Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30070640 | 0.82 | CA2 (0.44) | CA2SSTR4HTR1AADRA2AADRA2B | |
| SCHEMBL460126 | 0.82 | CA2 (0.44) | CA2SSTR4HTR1AADRA2AADRA2B | |
| Propionic Acid SCHEMBL28970782 | 0.78 | CA2 (0.42) | HPGDCA2TSHRCYP2D6SSTR4 | |
| Phosphoric Acid SCHEMBL4393635 | 0.77 | CA2 (0.42) | HPGDCA2TSHRCYP2D6HSD11B1 | |
| SCHEMBL531764 | 0.77 | CYP2C9 (0.49) | ALDH1A1KDM4ECA2PIN1CYP2C9 | |
| SCHEMBL29773128 | 0.77 | CYP2C9 (0.49) | ALDH1A1KDM4ECA2PIN1CYP2C9 | |
| SCHEMBL8981650 | 0.76 | CA2 (0.40) | HPGDCA2TSHRSSTR4HTR1A | |
| SCHEMBL3315636 | 0.75 | CYP11B1 (0.39) | ALDH1A1HSD17B10TSHRCYP2C9 | |
| SCHEMBL7597666 | 0.74 | TSHR (0.54) | ALDH1A1KDM4EHPGDCA2PIN1 | |
| SCHEMBL16964715 | 0.72 | TSHR (0.39) | HPGDCA2TSHRHTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498191-B2 | FOR TREATMENT OF ALZHEIMER'S DISEASE, DIABETES MELLITUS, PARKINSON'S DISEASE, NEURONAL AND CARDIAC ISCHEMIA, HUNTINGTON'S DISEASE, STROKE | MITOKOR | 2002-12-24 | — | — | US | disclosed |
| US-20020010195-A1 | Mitochondria protecting agents for treating mitochondria associated diseases | GHOSH SOUMITRA S (US) | 2002-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010195-A1 | Mitochondria protecting agents for treating mitochondria associated diseases | TFAM, HSPA9, HSPD1 | ALDH1A1 945/4885KDM4E 4364/4885HPGD 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.