Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 2/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7597915 | 0.95 | FOLH1 (0.38) | FOLH1CNR1CNR2CTSKMEN1 | |
| SCHEMBL7600478 | 0.95 | FOLH1 (0.38) | FOLH1CNR1CNR2CTSKMEN1 | |
| SCHEMBL7597936 | 0.92 | FOLH1 (0.40) | FOLH1MEN1LMNAKMT2ASIRT2 | |
| SCHEMBL7601629 | 0.92 | FOLH1 (0.40) | FOLH1MEN1LMNAKMT2ASIRT2 | |
| SCHEMBL7599024 | 0.89 | CA1 (0.42) | FOLH1CNR1CNR2CTSKTP53 | |
| SCHEMBL7595006 | 0.89 | CA1 (0.42) | FOLH1CNR1CNR2CTSKTP53 | |
| SCHEMBL8076494 | 0.87 | CNR1 (0.38) | MMP2MMP9FOLH1CNR1CNR2 | |
| SCHEMBL7595775 | 0.87 | MMP2 (0.35) | MMP2MMP9FOLH1CTSKTP53 | |
| SCHEMBL7600882 | 0.85 | TRPM8 (0.41) | FOLH1MEN1KMT2A | |
| SCHEMBL7595300 | 0.85 | TPSAB1 (0.39) | FOLH1MEN1KMT2ASIRT2TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017672-B1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 2002-11-27 | — | — | EP | disclosed |
| EP-1017672-A1 | NEW NPY ANTAGONISTS | AstraZeneca AB (SE) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015498-A1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 1999-04-01 | — | — | WO | disclosed |