Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7596641 | 0.92 | CNR1 (0.47) | TRPM8ALOX5CASRCNR1CNR2 | |
| SCHEMBL7595822 | 0.92 | CNR1 (0.47) | TRPM8ALOX5CASRCNR1CNR2 | |
| SCHEMBL7595142 | 0.89 | TRPM8 (0.41) | TRPM8MTNR1AMTNR1BTDP1ALOX5 | |
| SCHEMBL7595802 | 0.89 | TRPM8 (0.41) | TRPM8MTNR1AMTNR1BTDP1ALOX5 | |
| SCHEMBL7597372 | 0.89 | F2 (0.40) | TRPM8ALOX5F2F7CNR1 | |
| SCHEMBL7595325 | 0.87 | F7 (0.38) | TRPM8MTNR1AMTNR1BF2F7 | |
| SCHEMBL7600469 | 0.87 | TRPM8 (0.46) | TRPM8MTNR1AMTNR1BTDP1 | |
| Hydrochloric Acid SCHEMBL7601898 | 0.86 | TRPM8 (0.53) | TRPM8MTNR1AMTNR1BTDP1ALOX5 | |
| SCHEMBL7598351 | 0.85 | CNR1 (0.42) | TRPM8CNR1CNR2 | |
| SCHEMBL7596200 | 0.85 | TRPM8 (0.37) | TRPM8ALOX5CASRDRD3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017672-B1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 2002-11-27 | — | — | EP | claimed |
| EP-1017672-A1 | NEW NPY ANTAGONISTS | AstraZeneca AB (SE) | 2000-07-12 | — | — | EP | claimed |
| WO-1999015498-A1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 1999-04-01 | — | — | WO | claimed |
| EP-1017672-B1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 2002-11-27 | — | — | EP | disclosed |