Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.50 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.47 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31546635 | 0.84 | ALDH1A1 (0.64) | SMN1; SMN2LMNAMEN1KMT2APOLB | |
| SCHEMBL1531324 | 0.83 | POLB (0.60) | SMN1; SMN2LMNAMEN1KMT2APOLB | |
| SCHEMBL728206 | 0.83 | MEN1 (0.57) | SMN1; SMN2LMNAMEN1KMT2APOLB | |
| SCHEMBL28933885 | 0.82 | MEN1 (0.59) | SMN1; SMN2LMNAMEN1KMT2APOLB | |
| SCHEMBL5925546 | 0.81 | GAA (0.58) | SMN1; SMN2LMNAMEN1KMT2APOLB | |
| SCHEMBL7597164 | 0.81 | RORC (0.59) | SMN1; SMN2LMNAMEN1KMT2APOLB | |
| SCHEMBL570064 | 0.80 | TDP1 (0.57) | SMN1; SMN2LMNAMEN1KMT2APOLB | |
| SCHEMBL3884099 | 0.78 | TDP1 (0.58) | SMN1; SMN2LMNAMEN1KMT2APOLB | |
| Zinc Ion SCHEMBL9192290 | 0.78 | TDP1 (0.58) | SMN1; SMN2LMNAMEN1KMT2APOLB | |
| SCHEMBL15486505 | 0.78 | TDP1 (0.58) | SMN1; SMN2LMNAMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020137750-A1 | Amidine derivatives which are inhibitors of nitric oxide synthase | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137750-A1 | Amidine derivatives which are inhibitors of nitric oxide synthase | NOS1, NOS2, NOS3 | SMN1; SMN2 1582/4885LMNA 1976/4885MEN1 2000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.