Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7563353 | 0.88 | MEN1 (0.65) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL12041020 | 0.85 | MEN1 (0.62) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL28933885 | 0.83 | MEN1 (0.59) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL13844161 | 0.82 | ALDH1A1 (0.54) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL728206 | 0.82 | MEN1 (0.57) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL1531324 | 0.82 | POLB (0.60) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL6590271 | 0.81 | MEN1 (0.57) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL7597169 | 0.80 | MAPT (0.67) | KMT2AMEN1NPC1MAPTLMNA | |
| SCHEMBL15574696 | 0.80 | KMT2A (0.53) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL3888450 | 0.79 | TDP1 (0.57) | KMT2AMEN1NPC1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020137750-A1 | Amidine derivatives which are inhibitors of nitric oxide synthase | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137750-A1 | Amidine derivatives which are inhibitors of nitric oxide synthase | NOS1, NOS2, NOS3 | KMT2A 3787/4885MEN1 2000/4885NPC1 2983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.