Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7630436 | 0.94 | ALDH1A1 (0.42) | ALDH1A1LMNAHTTPKMSMN1; SMN2 | |
| SCHEMBL7595017 | 0.94 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2HTR1AHTR7HTR2A | |
| SCHEMBL7601057 | 0.92 | ALDH1A1 (0.48) | ALDH1A1LMNAHTR1AHTR7 | |
| SCHEMBL7608410 | 0.89 | PKM (0.42) | ALDH1A1LMNAHTTPKMSMN1; SMN2 | |
| SCHEMBL6766930 | 0.88 | ALDH1A1 (0.51) | ALDH1A1LMNAHTTPKMSMN1; SMN2 | |
| SCHEMBL7594407 | 0.88 | ALDH1A1 (0.45) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL7602690 | 0.86 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL7599828 | 0.85 | ALDH1A1 (0.41) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL7603029 | 0.85 | HTR1A (0.49) | HTR1AHTR2AHTR2C | |
| SCHEMBL7599324 | 0.84 | SMN1; SMN2 (0.46) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |