Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.42 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769580 | 0.88 | HTR1A (0.44) | HTR1AHTR2ADRD3HTR2CHTR7 | |
| SCHEMBL7603029 | 0.88 | HTR1A (0.49) | HTR1AHTR2ADRD3HTR2CDRD2 | |
| SCHEMBL7599963 | 0.88 | POLB (0.34) | CTNNB1TCF7L2 | |
| SCHEMBL7599394 | 0.87 | HTR1A (0.44) | HTR1AHTR2ADRD3HTR2CHTR7 | |
| SCHEMBL7600730 | 0.84 | HCRTR1 (0.40) | HTR1AHTR2ADRD3HTR2CDRD2 | |
| SCHEMBL7599324 | 0.84 | SMN1; SMN2 (0.46) | HTR2ADRD3HTR7DRD2DRD4 | |
| SCHEMBL7596191 | 0.84 | ALDH1A1 (0.49) | HTR1AHTR2AHTR2CHTR7HTR2B | |
| SCHEMBL7594980 | 0.81 | SMN1; SMN2 (0.46) | HTR1AHTR2ADRD3HTR2CHTR7 | |
| SCHEMBL7630436 | 0.81 | ALDH1A1 (0.42) | HTR1AHTR2ADRD3HTR2CHTR7 | |
| SCHEMBL7603379 | 0.81 | HTR1A (0.52) | HTR1AHTR2ADRD3HTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |