Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594980 | 0.97 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1ALOX15HPGDHTT | |
| SCHEMBL7601062 | 0.91 | RAB9A (0.54) | SMN1; SMN2DRD2HTR7GAARAB9A | |
| SCHEMBL6766414 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1ALOX15HPGDHTT | |
| SCHEMBL6770951 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1ALOX15HPGDHTT | |
| SCHEMBL7603029 | 0.85 | HTR1A (0.49) | DRD2DRD3HTR2A | |
| SCHEMBL7599394 | 0.84 | HTR1A (0.44) | ALDH1A1HPGDDRD2DRD3DRD4 | |
| SCHEMBL7596191 | 0.84 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1HTTHTR2AHTR7 | |
| SCHEMBL7598388 | 0.84 | NPC1 (0.44) | SMN1; SMN2DRD2DRD3LMNARAB9A | |
| SCHEMBL7599495 | 0.84 | HTR1A (0.42) | DRD2DRD3DRD4HTR2AHTR7 | |
| SCHEMBL7596525 | 0.83 | NPC1 (0.46) | SMN1; SMN2ALDH1A1LMNARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |