Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11146021 | 0.88 | LMNA (0.47) | ALOX15LMNACHRM2CYP2C19CHRNB2 | |
| SCHEMBL8939915 | 0.84 | CYP2D6 (0.51) | ALOX15LMNACHRM2CYP2C19CHRNB2 | |
| SCHEMBL28997029 | 0.84 | DNM1 (0.46) | ALOX15LMNACHRM2CYP2C19CHRNB2 | |
| SCHEMBL28163979 | 0.84 | DNM1 (0.46) | ALOX15LMNACHRM2CYP2C19CHRNB2 | |
| SCHEMBL28537728 | 0.82 | CHRNB2 (0.41) | ALOX15LMNACHRM2CYP2C19CHRNB2 | |
| SCHEMBL26300274 | 0.80 | ALDH1A1 (0.54) | LMNACHRM2CHRNB2CHRNA4CHRM4 | |
| SCHEMBL6407909 | 0.80 | CHRNB2 (0.40) | ALOX15LMNACHRM2CYP2C19CHRNB2 | |
| SCHEMBL31298793 | 0.79 | LMNA (0.55) | ALOX15LMNACHRM2CYP2C19CHRNB2 | |
| SCHEMBL26521321 | 0.79 | CHRNB2 (0.61) | ALOX15LMNACHRM2CYP2C19CHRNB2 | |
| SCHEMBL11861419 | 0.78 | NAAA (0.52) | LMNACHRM2CYP2C19CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | disclosed |