Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.36 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL40555 | 0.84 | MAPT (0.50) | MAPTHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL30165715 | 0.82 | KMT2A (0.50) | MAPTHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL146313 | 0.82 | KMT2A (0.50) | MAPTHTTKDM4ESMN1; SMN2ALDH1A1 | |
| Iodide SCHEMBL11279046 | 0.80 | KMT2A (0.48) | MAPTHTTKDM4ESMN1; SMN2ALDH1A1 | |
| Acetic Acid SCHEMBL755555 | 0.77 | NQO2 (0.42) | MAPTHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL12620639 | 0.76 | KDM4E (0.43) | MAPTHTTKDM4ESMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL333986 | 0.74 | KDM4E (0.39) | MAPTHTTKDM4ESMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL137066 | 0.74 | APAF1 (0.46) | MAPTHTTKDM4ESMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29594522 | 0.74 | APAF1 (0.46) | MAPTHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL12273001 | 0.74 | HTR3A (0.48) | MAPTHTTKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248824-A2 | NOVEL COLORANTS, COLORANT STABILIZERS, INK COMPOSITIONS, AND IMPROVED METHODS OF MAKING THE SAME | Kimberly-Clark Worldwide, Inc. (US) | 2002-10-16 | — | — | EP | disclosed |
| WO-2001051572-A2 | NOVEL COLORANTS, COLORANT STABILIZERS, INK COMPOSITIONS, AND IMPROVED METHODS OF MAKING THE SAME | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2001-07-19 | — | — | WO | disclosed |