Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 4/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999984 | 0.86 | HSP90AA1 (0.49) | HSP90AA1RORCCNR2MEN1HTT | |
| SCHEMBL6158774 | 0.83 | KMT2A (0.50) | MEN1HTTKMT2AL3MBTL1CA2 | |
| SCHEMBL7601922 | 0.80 | KMT2A (0.48) | MEN1HTTKMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL10900809 | 0.79 | HSP90AA1 (0.52) | HSP90AA1RORCCNR2KMT2ATSHR | |
| SCHEMBL224787 | 0.78 | HSP90AA1 (0.55) | HSP90AA1RORCCNR2SMN1; SMN2HSD17B10 | |
| SCHEMBL18016435 | 0.78 | HSP90AA1 (0.55) | HSP90AA1RORCCNR2MEN1KMT2A | |
| SCHEMBL14873489 | 0.77 | RORC (0.47) | HSP90AA1RORCCNR2MEN1HTT | |
| SCHEMBL2448054 | 0.76 | RIPK1 (0.47) | CNR2MEN1HTTKMT2AL3MBTL1 | |
| SCHEMBL16187647 | 0.76 | RORC (0.46) | HSP90AA1RORCCNR2KMT2ATSHR | |
| SCHEMBL3174757 | 0.72 | HSP90AA1 (0.57) | HSP90AA1CNR2MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946502-B1 | SULFONAMIDE INTERLEUKIN-BETA CONVERTING ENZYME INHIBITORS | WARNER LAMBERT CO (US) | 2002-12-18 | — | — | EP | disclosed |
| US-20020156094-A1 | Sulfonamide interleukin-1beta converting enzyme inhibitors | WARNER-LAMBERT COMPANY | 2002-10-24 | — | — | US | disclosed |
| US-6316415-B1 | INHIBITORS OF INTERLEUKIN-1.BETA. CONVERTING ENZYME THAT HAVE THE TREATMENT OF STROKE, REPERFUSION INJURY, ALZHEIMER'S DISEASE, SHIGELLOSIS, INFLAMMATORY DISEASES, SEPTIC SHOCK AND TO AN INHIBITOR OF INTERLEUKIN-1.BETA. CONVERTING ENZYME. | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156094-A1 | Sulfonamide interleukin-1beta converting enzyme inhibitors | IL1A, IL1B, IL1R1 | HSP90AA1 688/4885RORC 1517/4885CNR2 4000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.