Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269421 | 0.80 | CES2 (0.50) | CES2CES1TDP1L3MBTL1POLB | |
| SCHEMBL10739032 | 0.73 | ALDH1A1 (0.53) | TDP1L3MBTL1POLBMAPTRAB9A | |
| SCHEMBL4240902 | 0.71 | AKR1B1 (0.45) | CES2CES1RAB9ANPC1TP53 | |
| SCHEMBL31711605 | 0.71 | CES2 (0.55) | CES2CES1TDP1L3MBTL1POLB | |
| SCHEMBL11015620 | 0.70 | CES2 (0.42) | CES2CES1TDP1L3MBTL1POLB | |
| SCHEMBL1515773 | 0.70 | CES2 (0.53) | CES2CES1POLBMAPTRAB9A | |
| SCHEMBL8584 | 0.70 | CES2 (0.63) | CES2CES1L3MBTL1RAB9AACKR3 | |
| SCHEMBL10415018 | 0.70 | MAPT (0.38) | L3MBTL1POLBMAPTMEN1KMT2A | |
| SCHEMBL7269432 | 0.70 | IDO1 (0.46) | CES2CES1TDP1L3MBTL1POLB | |
| SCHEMBL5325941 | 0.69 | CES2 (0.57) | CES2CES1L3MBTL1ACKR3ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194742-A1 | Antifungal Compounds | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2018-07-12 | — | — | US | disclosed |
| EP-2337562-B1 | ANTIFUNGAL COMPOUNDS CONTAINING BENZOTHIAZINONE, BENZOXAZINONE OR BENZOXAZOLINONE AND PROCESS THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-07-24 | — | — | EP | disclosed |
| EP-2346861-B1 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-01-23 | — | — | EP | disclosed |
| US-8236840-B2 | Thiopene containing analogues of fluconazole as antifungal agents and process for their preparation | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-08-07 | — | — | US | disclosed |
| US-8129369-B2 | Antifungal compounds containing benzothiazinone, benzoxazinone or benzoxazolinone and process thereof | Council of Scientific & Industrial Research; (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110183968-A1 | ANTIFUNGAL COMPOUNDS CONTAINING BENZOTHIAZINONE, BENZOXAZINONE OR BENZOXAZOLINONE AND PROCESS THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-07-28 | — | — | US | disclosed |
| EP-2346861-A2 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | Council of Scientific and Industrial Research (IN) | 2011-07-27 | — | — | EP | disclosed |
| EP-2337562-A2 | ANTIFUNGAL COMPOUNDS CONTAINING BENZOTHIAZINONE, BENZOXAZINONE OR BENZOXAZOLINONE AND PROCESS THEREOF | Council of Scientific & Industrial Research (IN) | 2011-06-29 | — | — | EP | disclosed |
| US-20110144171-A1 | THIOPENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS FOR THEIR PREPARATION | COUNCIL OF SCIENCE & INDUSTRIAL RESEARCH (IN) | 2011-06-16 | — | — | US | disclosed |
| WO-2010046912-A2 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010046931-A2 | ANTIFUNGAL COMPOUNDS CONTAINING BENZOTHIAZINONE, BENZOXAZINONE OR BENZOXAZOLINONE AND PROCESS THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-04-29 | — | — | WO | disclosed |
| EP-0871625-B1 | PREPARATION OF TRIAZOLES BY ORGANOMETALLIC ADDITION TO KETONES AND INTERMEDIATES THEREFOR | PFIZER RES ANDDEVELOPMENT COMP (IE) | 2003-12-17 | — | — | EP | disclosed |
| EP-0835252-A1 | TRIAZOLE ANTIFUNGAL AGENTS | Pfizer Research and Development Company, N.V./S.A. (IE) | 1998-04-15 | — | — | EP | disclosed |
| US-5710280-A | Preparation of fluconazole and pharmaceutically acceptable salts thereof | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 1998-01-20 | — | — | US | disclosed |
| EP-0357241-B1 | Triazole antifungal agents | PFIZER LTD (GB) | 1994-02-16 | — | — | EP | disclosed |
| EP-0546529-A1 | Triazole derivatives and salts thereof, processes for producing the same, and antifungal agent containing the same | TOYAMA CHEMICAL CO., LTD. (JP) | 1993-06-16 | — | — | EP | disclosed |
| EP-0122056-A1 | Triazole antifungal agents | Pfizer Limited (GB) | 1984-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194742-A1 | Antifungal Compounds | ERG28, DPM1, CYP51A1 | CES2 1930/4885CES1 2717/4885TDP1 2729/4885 |
| US-20110144171-A1 | THIOPENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS FOR THEIR PREPARATION | CYP51A1, ERG28, TPMT | CES2 2815/4885CES1 1167/4885TDP1 1334/4885 |
| US-20110183968-A1 | ANTIFUNGAL COMPOUNDS CONTAINING BENZOTHIAZINONE, BENZOXAZINONE OR BENZOXAZOLINONE AND PROCESS THEREOF | CYP51A1, XPO1, XPO5 | CES2 3894/4885CES1 1755/4885TDP1 3244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.