Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL8072957 | 0.86 | TDP1 (0.77) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL20478 | 0.86 | — | — | |
| Propylene Glycol SCHEMBL28302926 | 0.86 | TDP1 (0.77) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL8081763 | 0.86 | TDP1 (0.77) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL29254418 | 0.84 | TDP1 (0.48) | TDP1TSHRMAPK1 | |
| Propylene Glycol SCHEMBL2840491 | 0.84 | TDP1 (0.62) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL27529046 | 0.83 | — | — | |
| Propylene Glycol SCHEMBL19514495 | 0.83 | — | — | |
| Propylene Glycol SCHEMBL7522896 | 0.82 | TDP1 (1.00) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL28578 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536683-B1 | POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION | ASAHI CHEMICAL IND (JP) | 2021-11-24 | — | — | EP | disclosed |
| CN-107963982-B | Polyisocyanate composition and isocyanate polymer composition | 旭化成株式会社 | 2021-11-12 | — | — | CN | disclosed |
| EP-3372579-B1 | POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION | ASAHI CHEMICAL IND (JP) | 2020-10-28 | — | — | EP | disclosed |
| CN-107636033-B | Polyisocyanate composition, polyurethane resin, and two-pack type curable polyurethane composition | 三井化学株式会社 | 2020-10-13 | — | — | CN | disclosed |
| EP-2915803-B1 | POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION | ASAHI CHEMICAL IND (JP) | 2020-07-22 | — | — | EP | disclosed |
| EP-3536683-A1 | POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION | Asahi Kasei Kabushiki Kaisha (JP) | 2019-09-11 | — | — | EP | disclosed |
| CN-105254843-B | Polyisocyantates composition, blocked polyisocyanates composition and their manufacturing method | 旭化成株式会社 | 2019-08-06 | — | — | CN | disclosed |
| US-10301417-B2 | Polyisocyanate composition and isocyanate polymer composition | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2019-05-28 | — | — | US | disclosed |
| US-10125212-B2 | Polyisocyanate composition and isocyanate polymer composition | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2018-11-13 | — | — | US | disclosed |
| CN-106008269-B | Polyisocyantates composition and isocyanate polymer composition | 旭化成株式会社 | 2018-10-19 | — | — | CN | disclosed |
| CN-104619682-A | Polyisocyanate composition and isocyanate polymer composition | ASAHI KASEI CHEMICALS CORP | 2015-05-13 | — | — | CN | disclosed |
| CN-101646718-B | Curable resin composition, protective film, and method for forming protective film | JSR CORP JP | 2013-04-03 | — | — | CN | disclosed |
| CN-102898149-A | Solvent or solvent composition for manufacturing laminated ceramic member | DAICEL CHEM | 2013-01-30 | — | — | CN | disclosed |
| CN-101646718-A | The formation method of curable resin composition, protective membrane and protective membrane | JSR CORP JP | 2010-02-10 | — | — | CN | disclosed |
| CN-1163476-C | Biuret polyisocyanic acid ester and its producing process | 旭化成株式会社 | 2004-08-25 | — | — | CN | disclosed |
| EP-0848007-B1 | Silylated ultraviolet light absorbers | GEN ELECTRIC (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-0854127-B1 | Novel compounds based on dibenzoylresorcinol and related compositions and articles | GEN ELECTRIC (US) | 2002-04-17 | — | — | EP | disclosed |
| CN-1335302-A | Biuret polyisocyanic acid ester and its producing process | ASAHI CHEMICAL IND (JP) | 2002-02-13 | — | — | CN | disclosed |
| EP-0854127-A1 | Novel compounds based on dibenzoylresorcinol and related compositions and articles | GENERAL ELECTRIC COMPANY (US) | 1998-07-22 | — | — | EP | disclosed |
| EP-0848007-A1 | Silylated ultraviolet light absorbers | GENERAL ELECTRIC COMPANY (US) | 1998-06-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10301417-B2 | Polyisocyanate composition and isocyanate polymer composition | PAH, ALKBH1, ALKBH3 | TDP1 621/4885TSHR 4682/4885ALDH1A1 427/4885 |
| US-10125212-B2 | Polyisocyanate composition and isocyanate polymer composition | TST, SUDS3, SCLY | TDP1 4009/4885TSHR 4448/4885ALDH1A1 2991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.