Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 8/20 | 0.44 |
| ▸ | HTR7 | P34969 | 8/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7599324 | 0.91 | SMN1; SMN2 (0.46) | RAB9AMAPTSMN1; SMN2HTR7DRD2 | |
| SCHEMBL6769569 | 0.90 | RAB9A (0.55) | RAB9AMAPTSMN1; SMN2HTR1AHTR7 | |
| SCHEMBL7594980 | 0.88 | SMN1; SMN2 (0.46) | RAB9ASMN1; SMN2HTR1AHTR7DRD2 | |
| SCHEMBL6767142 | 0.87 | RAB9A (0.52) | RAB9AMAPTSMN1; SMN2HTR1AHTR7 | |
| SCHEMBL7599780 | 0.85 | SLC6A2 (0.48) | HTR1AHTR7DRD2HTR6 | |
| SCHEMBL7601057 | 0.85 | ALDH1A1 (0.48) | MAPTHTR1AHTR7DRD2HTR6 | |
| SCHEMBL7723383 | 0.83 | HTR1A (0.53) | HTR1AHTR7DRD2HTR6 | |
| SCHEMBL7600225 | 0.82 | HTR1A (0.48) | MAPTHTR1AHTR7DRD2HTR6 | |
| SCHEMBL7598388 | 0.81 | NPC1 (0.44) | RAB9AMAPTSMN1; SMN2DRD2CYP1A2 | |
| SCHEMBL6766414 | 0.80 | SMN1; SMN2 (0.47) | RAB9AMAPTSMN1; SMN2HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |