Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 14/20 | 0.45 |
| ▸ | HTR7 | P34969 | 13/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | HTR6 | P50406 | 5/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595017 | 0.93 | ALDH1A1 (0.56) | ALDH1A1HTR1AHTR7DRD2 | |
| SCHEMBL7596191 | 0.92 | ALDH1A1 (0.49) | ALDH1A1HTR1AHTR7LMNA | |
| SCHEMBL6771329 | 0.89 | ALDH1A1 (0.49) | ALDH1A1HTR1AHTR7MAPTLMNA | |
| SCHEMBL7594407 | 0.87 | ALDH1A1 (0.45) | ALDH1A1LMNA | |
| SCHEMBL7599780 | 0.86 | SLC6A2 (0.48) | HTR1AHTR7DRD2HTR6SLC6A2 | |
| SCHEMBL7602690 | 0.86 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL7601062 | 0.85 | RAB9A (0.54) | HTR1AHTR7MAPTDRD2HTR6 | |
| SCHEMBL7630436 | 0.85 | ALDH1A1 (0.42) | ALDH1A1HTR1AHTR7MAPTLMNA | |
| SCHEMBL7723383 | 0.84 | HTR1A (0.53) | HTR1AHTR7DRD2HTR6 | |
| SCHEMBL7599828 | 0.83 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |