SCHEMBL7602487

SCHEMBL7602487

CCCCOc1c(NC(C)(C)CC)c(=O)c1=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADAMTS5 Q9UNA0 2/20 0.37
GAA P10253 2/20 0.36
PLK1 P53350 1/20 0.34
POLB P06746 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
SLC6A5 Q9Y345 1/20 0.33
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA3 P07451 1/20 0.32
CA4 P22748 1/20 0.32
CA6 P23280 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32
CA5B Q9Y2D0 1/20 0.32
THRA P10827 1/20 0.32
THRB P10828 1/20 0.32
LMNA P02545 1/20 0.32
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7887050 0.88 SMN1; SMN2 (0.41) ADAMTS5GAAPOLBSMN1; SMN2SLC6A5
SCHEMBL7597357 0.87 ADAMTS5 (0.38) ADAMTS5GAAPOLBSMN1; SMN2SLC6A5
SCHEMBL7599517 0.83 GAA (0.46) GAAPLK1POLBMAPT
SCHEMBL7597268 0.75 PLK1 (0.43) ADAMTS5PLK1POLB
Squaric Acid Dibutyl Ester SCHEMBL56180 0.74 CYP3A4 (0.44) CA12CA1CA2CA3CA4
SCHEMBL9749261 0.73 ADAMTS5 (0.36) ADAMTS5GAAPOLBSMN1; SMN2CA12
SCHEMBL9748925 0.73 ADAMTS5 (0.39) ADAMTS5GAAPOLBTHRATHRB
SCHEMBL7604367 0.72 ADAMTS5 (0.38) ADAMTS5GAAPOLBCA12CA1
SCHEMBL8604153 0.71 POLB (0.39) ADAMTS5GAAPLK1POLBTHRA
SCHEMBL22878978 0.70 GAA (0.44) GAAPOLBMAPTNPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934257-B1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES WYETH CORP (US) 2002-12-11 EP disclosed
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP disclosed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 EP disclosed
EP-0927034-A1 METHOD OF TREATING URINARY INCONTINENCE AMERICAN HOME PRODUCTS CORPORATION (US) 1999-07-07 EP disclosed
EP-0906282-A1 HETEROCYCLYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AS POTASSIUM CHANNEL MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-04-07 EP disclosed
US-5872139-A MUSCLE RELAXANTS USED TO TREAT URINARY INCONTINENCE, IRRITABLE BOWEL SYNDROME, ASTHMA, PREMATURE LABOR, CONGESTIVE HEART FAILURE, ANGINA, CEREBRAL VASCULAR DISEASE AND HYPERTENSION AMERICAN HOME PRODUCTS CORPORATION (US) 1999-02-16 US disclosed
US-5780505-A ADMINISTERING AS SMOOTH MUSCLE RELAXANT AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-14 US disclosed
US-5763474-A SMOOTH MUSCLE RELAXANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1998-06-09 US disclosed
WO-1998011888-A1 METHOD OF TREATING URINARY INCONTINENCE AMERICAN HOME PRODUCTS CORPORATION (US) 1998-03-26 WO disclosed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 WO disclosed
WO-1997048682-A1 HETEROCYCLYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AS POTASSIUM CHANNEL MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 1997-12-24 WO disclosed