SCHEMBL7597357

SCHEMBL7597357

CCCCOc1c(NC(C)(C)C)c(=O)c1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADAMTS5 Q9UNA0 2/20 0.38
GAA P10253 2/20 0.38
POLB P06746 1/20 0.35
SLC6A5 Q9Y345 1/20 0.34
THRA P10827 1/20 0.33
THRB P10828 1/20 0.33
SLC2A1 P11166 1/20 0.33
MAPT P10636 3/20 0.33
ALDH1A1 P00352 2/20 0.33
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
KMT2A Q03164 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
KDM4E B2RXH2 1/20 0.32
LMNA P02545 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
CNR2 P34972 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CYP3A4 P08684 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7602487 0.87 ADAMTS5 (0.37) ADAMTS5GAAPOLBSLC6A5THRA
SCHEMBL7887050 0.84 SMN1; SMN2 (0.41) ADAMTS5GAAPOLBSLC6A5THRA
SCHEMBL7598100 0.82 GAA (0.49) GAAPOLBMAPT
SCHEMBL7597268 0.78 PLK1 (0.43) ADAMTS5POLB
Squaric Acid Dibutyl Ester SCHEMBL56180 0.77 CYP3A4 (0.44) THRATHRBMAPTALDH1A1KDM4E
SCHEMBL7604367 0.75 ADAMTS5 (0.38) ADAMTS5GAAPOLBTHRATHRB
SCHEMBL8604153 0.73 POLB (0.39) ADAMTS5GAAPOLBTHRATHRB
SCHEMBL9749261 0.72 ADAMTS5 (0.36) ADAMTS5GAAPOLBTHRATHRB
SCHEMBL9748925 0.72 ADAMTS5 (0.39) ADAMTS5GAAPOLBTHRATHRB
SCHEMBL9809602 0.71 THRA (0.44) THRATHRBCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934257-B1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES WYETH CORP (US) 2002-12-11 EP disclosed
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP disclosed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 EP disclosed
EP-0927034-A1 METHOD OF TREATING URINARY INCONTINENCE AMERICAN HOME PRODUCTS CORPORATION (US) 1999-07-07 EP disclosed
US-5780505-A ADMINISTERING AS SMOOTH MUSCLE RELAXANT AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-14 US disclosed
US-5763474-A SMOOTH MUSCLE RELAXANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1998-06-09 US disclosed
WO-1998011888-A1 METHOD OF TREATING URINARY INCONTINENCE AMERICAN HOME PRODUCTS CORPORATION (US) 1998-03-26 WO disclosed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 WO disclosed