SCHEMBL7604367

SCHEMBL7604367

CCCCOc1c(NC(CC)CC)c(=O)c1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADAMTS5 Q9UNA0 2/20 0.38
POLB P06746 1/20 0.37
CNR2 P34972 2/20 0.36
MAPT P10636 3/20 0.35
GAA P10253 2/20 0.35
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
ALDH1A1 P00352 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CXCR1 P25024 1/20 0.33
CXCR2 P25025 1/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
TSHR P16473 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
CCNE2 O96020 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8598123 0.90 HDAC1 (0.36) ADAMTS5POLBCNR2MAPTGAA
SCHEMBL23919414 0.82 POLB (0.47) POLBMAPTGAACXCR1CXCR2
SCHEMBL8604153 0.82 POLB (0.39) ADAMTS5POLBCNR2MAPTGAA
SCHEMBL7597268 0.80 PLK1 (0.43) ADAMTS5POLB
SCHEMBL9749015 0.77 CCNE2 (0.42) ADAMTS5MAPTGAAALDH1A1MEN1
Squaric Acid Dibutyl Ester SCHEMBL56180 0.75 CYP3A4 (0.44) MAPTALDH1A1CA12CA1CA2
SCHEMBL7597357 0.75 ADAMTS5 (0.38) ADAMTS5POLBCNR2MAPTGAA
SCHEMBL7602487 0.72 ADAMTS5 (0.37) ADAMTS5POLBMAPTGAANPC1
SCHEMBL9749261 0.71 ADAMTS5 (0.36) ADAMTS5POLBMAPTGAANPC1
SCHEMBL9748925 0.71 ADAMTS5 (0.39) ADAMTS5POLBCNR2MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934257-B1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES WYETH CORP (US) 2002-12-11 EP disclosed
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP disclosed
US-5780505-A ADMINISTERING AS SMOOTH MUSCLE RELAXANT AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-14 US disclosed
US-5763474-A SMOOTH MUSCLE RELAXANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1998-06-09 US disclosed