Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.32 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.32 |
| ▸ | CCKBR | P32239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765216 | 0.84 | DRD2 (0.36) | MAPTMAOBNPC1RAB9ACA12 | |
| SCHEMBL781907 | 0.81 | GPR119 (0.37) | LMNAMAPTHTTBLM | |
| SCHEMBL25340956 | 0.78 | LMNA (0.40) | LMNAMAPTHTTBLMPIK3CA | |
| SCHEMBL1855164 | 0.71 | LMNA (0.52) | LMNAMAPTHTTBLMALDH1A1 | |
| SCHEMBL759673 | 0.69 | MAPT (0.43) | LMNAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL3789225 | 0.69 | RIPK1 (0.46) | LMNAMAPTHTTBLMPIK3CA | |
| SCHEMBL783121 | 0.67 | ESR2 (0.42) | — | |
| SCHEMBL23832722 | 0.67 | MAPT (0.34) | LMNAMAPTHTTBLMPIK3CA | |
| SCHEMBL755596 | 0.66 | KEAP1 (0.61) | LMNAMAPTHTTBLMMAOB | |
| SCHEMBL17957863 | 0.66 | HCRTR2 (0.47) | LMNAMAPTHTTBLMPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431360-B1 | Derivatives of dihydrobenzoxathiazepine, method of preparing same and pharmaceutical compositions containing them as well as their uses as modulators of AMPA receptors | SERVIER LAB (FR) | 2013-04-17 | — | — | EP | disclosed |
| EP-2431360-A1 | Derivatives of dihydrobenzoxathiazepine, method of preparing same and pharmaceutical compositions containing them as well as their uses as modulators of AMPA receptors | Les Laboratoires Servier (FR) | 2012-03-21 | — | — | EP | disclosed |