Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 14/20 | 0.45 |
| ▸ | MAOA | P21397 | 6/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610066 | 0.78 | MAOA (0.41) | MAOBMAOAHPGD | |
| SCHEMBL7604066 | 0.75 | SIGMAR1 (0.40) | MAOBMAOA | |
| SCHEMBL7601929 | 0.72 | PDK2 (0.37) | PARP10HPGD | |
| SCHEMBL891195 | 0.69 | MAOB (0.69) | NPC1RAB9AMAOBMAOAHRH3 | |
| SCHEMBL762195 | 0.69 | MAOB (0.69) | NPC1RAB9AMAOBMAOAHRH3 | |
| SCHEMBL8930213 | 0.69 | MAOB (0.69) | NPC1RAB9AMAOBMAOAHRH3 | |
| SCHEMBL8929713 | 0.69 | MAOB (0.69) | NPC1RAB9AMAOBMAOAHRH3 | |
| SCHEMBL31686125 | 0.68 | IDO1 (0.35) | ACHESMN1; SMN2 | |
| SCHEMBL18636228 | 0.67 | MAOB (0.56) | NPC1RAB9AMAOBMAOAACHE | |
| SCHEMBL5090229 | 0.67 | MAOB (0.56) | NPC1RAB9AMAOBMAOAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265848-A2 | AMINES SUBSTITUTED WITH A DIHYDRONAPHTHALENYL, CRHOMENYL, OR THIOCHROMENYL GROUP, AN ARYL OR HETEROARYL GROUP AND AN ALKYL GROUP, HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan Sales, Inc. (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001070668-A2 | AMINES SUBSTITUTED WITH A DIHYDRONAPHTHALENYL, CRHOMENYL, OR THIOCHROMENYL GROUP, AN ARYL OR HETEROARYL GROUP AND AN ALKYL GROUP, HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 2001-09-27 | — | — | WO | disclosed |